OUR VISION

The natural world consists of hierarchical levels of complexity that range from subatomic particles and molecules to ecosystems and beyond.

This implies that, in order to explain the features and behavior of a whole system, a theory might be required that would operate at the corresponding hierarchical level, i.e. where self-organization processes take place.

In the past, biological research has focused on questions that could be addressed by a reductionist program of genetics.

The organism (and its development) is currently considered an epiphenomenon of its genes. However, a profound rethinking of the biological paradigm is now underway and it is likely that such a process will lead to a conceptual revolution emerging from the ashes of reductionism.

This revolution implies the search for general principles on which a cogent theory of biology might rely. Because much of the logic of living systems is located at higher levels, it is imperative to focus on them. Indeed, both evolution and physiology work on these levels.

Thus, by no means Systems Biology could be viewed a ‘simple’ ‘gradual’ extension of Molecular Biology.

OBJECTIVES

The main objective of the initiative is to pool the capabilities and potential of the scientific actors, clinicians and stakeholders, starting an activity that is capable of self-sustaining, generating scientific, clinical and economic results. Technology Transfer Table. The laboratory’s activities will be supported through the establishment of a Technology Transfer Table, to which stakeholders and research institutions interested in the applications of the results achieved will be invited, according to a scheduled deadline. Deliverables. Operational, the collaboration will allow the marketing of a series of services for the implementation of medical and biological tests. A special attention will be paid in obtaining patents for new devices and drugs. Furthermore, the cooperation in between scientists and clinician is thought to be instrumental in establishing advanced therapeutic protocols.

SBGLab Team

Mariano
Bizzarri

Mariano Bizzarri PhD, M.D., is Associate Professor of Clinical Pathology in the Department of Experimental Medicine at University Sapienza, Rome (Italy).

Alessandra
Cucina

Alessandra Cucina PhD, is a researcher at the Laboratory of Experimental Research Castro Laurenziano of “Pietro Valdoni” Department of Surgery, “La Sapienza” University, Rome, Italy.

Alessandro Giuliani ISS

Alessandro
Giuliani

Alessandro Giuliani is involved since more than thirty years in the generation and testing of soft physical and statistical models for life sciences.

Sara
Proietti

Dr. Sara Proietti, is a post-doc researcher affiliated to the Department of Surgery P. Valdoni at the University La Sapienza of Rome.

Andrea
Fuso

Andrea Fuso, Ph.D., is guest researcher at Sapienza University of Rome, Department of Surgery “P. Valdoni”, and scientific consultant for Lo.Li.Pharma.

Andrea
Pensotti

Graduated in Pharmaceutical Chemistry at University of Milan in 2009, he finalized his studies with a professional master in management in London.

Rosaria A.
Cavallaro

Rosaria A. Cavallaro, PhD., is a Research Associate at Sapienza University of Rome, Department of Surgery “P. Valdoni”, Laboratory of experimental research “Castro Laurenziano”.

Maria Grazia
Masiello

Maria Grazia Masiello, PhD, is a Postdoctoral Researcher in the Department of Surgery “P. Valdoni” at University Sapienza, Rome (Italy).

Simona
Dinicola

Dr. Simona Dinicola, is a post-doc researcher affiliated to the Department of Experimental Medicine at the University La Sapienza of Rome.

Myselis
Santiago-Reyes

Myselis Santiago-Reyes earned her Master’s Degree in Genetics and Molecular Biology on December, 2017 at La Sapienza University in Rome, Italy.

Gianmarco
Fabrizi

Gianmarco Fabrizi, is a student of the Faculty of pharmacy and medicine, at the University La Sapienza of Rome.

Mirko
Minini

Ph.D. student Mirko Minini received a Master’s Degree from ‘La Sapienza’ University of Rome in Genetics and Molecular Biology cum laude.

Corresponding Authors

Professor of Human Genetics

Roberto Taramelli

Professor in the Department of Integrative Physiology and Pathobiology

Ana Soto

Professor at Tufts University School of Medicine

Carlos Sonnenschein

Directeur de Recherche (DRE) CNRS at Centre Interdisciplinaire Cavaillès

Giuseppe Longo

Professore Ordinario di Biologia Applicata

Arturo Bevilacqua

Aggregate Professor

Giulia Ricci

Chiara Simeoni

corrado mascia
Associate Professor Mathematics Department G.Castelnuovo

Corrado Mascia

Professore Ordinario di Patologia Clinica

Roberto Verna

Professor of Human Genetics

Roberto Taramelli

My interests have been, from the beginning of my scientific career, within the field of human genetics. I started with the study of the genetic determinants of thalassemias syndromes in particular I was looking for genetic variations in the beta globin cluster associated with these disorders (National Institute for Medical Research London). Then I continued focusing on more complex pathologies like the dislipidemias where I contributed to the molecular characterization of a genetic determinant (apoliprprotein (a)) with a strong effect on susceptibility to early coronary diseases (Rockefeller University, New York). The apo(a) gene happened to be located in a genomic region frequently rearranged in a substantial number of different cancers ranging from solid to hemotalogical malignancies. This prompted my group to construct (manually, as no databases were available at that time of the early ‘80s) a physical and transcriptional map of that region (6q26-27) University of Milan, Milan). Among several genes isolated, one which codes for an extracellular RNase phylogenetically highly conserved among the taxa, caught our interest. This RNase turned out to be a pleiotropic protein acting within the cellular microenvironment where it recruits macrophages and other immunological competent cells. It is also acting to influence the structural architecture of, for instance, mammary cells when studied with organoids model systems University of Insubria, Varese). The latter findings led us to start investigating at a more general level and leveraging on the conceptual tools of systems dynamics, the interaction dynamics of different cell populations within the cancer tissues.

Selected papers:

1: Zhou JX, Taramelli R, Pedrini E, Knijnenburg T, Huang S. Extracting Intercellular Signaling Network of Cancer Tissues using Ligand-Receptor Expression Patterns from Whole-tumor and Single-cell Transcriptomes. Sci Rep. 2017;7(1):8815.

2: Lualdi M, Pedrini E, Rea K, Monti L, Scaldaferri D, Gariboldi M, Camporeale A, Ghia P, Monti E, Tomassetti A, Acquati F, Taramelli R. Pleiotropic modes of action in tumor cells of RNASET2, an evolutionary highly conserved extracellular RNase. Oncotarget. 2015;6(10):7851-65.

3: Acquati F, Lualdi M, Bertilaccio S, Monti L, Turconi G, Fabbri M, Grimaldi A, Anselmo A, Inforzato A, Collotta A, Cimetti L, Riva C, Gribaldo L, Ghia P, Taramelli R. Loss of function of Ribonuclease T2, an ancient and phylogenetically conserved RNase, plays a crucial role in ovarian tumorigenesis. Proc Natl Acad

Sci U S A. 2013;110(20):8140-5.

4: Acquati F, Monti L, Lualdi M, Fabbri M, Sacco MG, Gribaldo L, Taramelli R. Molecular signature induced by RNASET2, a tumor antagonizing gene, in ovarian cancer cells. Oncotarget. 2011 (6):477-84. Review.

5: Acquati F, Bertilaccio S, Grimaldi A, Monti L, Cinquetti R, Bonetti P, Lualdi M, Vidalino L, Fabbri M, Sacco MG, van Rooijen N, Campomenosi P, Vigetti D, Passi A, Riva C, Capella C, Sanvito F, Doglioni C, Gribaldo L, Macchi P, Sica A, Noonan DM, Ghia P, Taramelli R. Microenvironmental control of malignancy exerted by

RNASET2, a widely conserved extracellular RNase. Proc Natl Acad Sci U S A. 2011;108(3):1104-9.

Professor in the Department of Integrative Physiology and Pathobiology

Ana Soto

Ana Soto is a professor in the Department of Integrative Physiology and Pathobiology at Tufts University School of Medicine, in Boston, MA, and Membre Correspondent Etranger at the Centre Cavaillès, Ecole Normale Supérieure, Paris. She was a professor of Cancer Development at the University of Ulster and the Blaise Pascal Chair in Biology 2013-15 at the Ecole Normale Supérieure of Paris. For over three decades, Dr Soto’s research interests have centered on a) the control of cell proliferation by sex steroids, b) the developmental origins of adult disease, particularly the role of endocrine disruptors on carcinogenesis, reproduction and obesity, c) the role of stroma/epithelial interactions on organogenesis and carcinogenesis and d) the role of biomechanics on morphogenesis.

Dr. Soto also works on theoretical and epistemological issues arising from the study of complex biological phenomena. In this regard, in partnership with Professor Carlos Sonnenschein, she co-authored a book entitled THE SOCIETY OF CELLS (Bios-Springer-Verlag, 1999, published also in French in 2006, in Spanish in 2017 and it is now being translated to Italian). They posited that the default state of cells in all organisms is proliferation, and proposed the Tissue Organization Field Theory of Carcinogenesis, in which cancer is viewed as development gone awry. As the Blaise Pascal Chair in Biology, she coordinated a multidisciplinary working group devoted to the elaboration of a theory of organisms; this work was published as a special issue of Progress in Biophysics and Molecular Biology (Soto, AM, Longo, G Noble, D, editors: From the century of the genome to the century of the organism: New theoretical approaches. Prog. Biophys. Mol. Biol, 122:1, 2016).

Dr. Soto is the recipient of several awards, including the 2012 Gabbay Biotechnology & Medicine Award of Brandeis University, presented to her, Dr. Sonnenschein and Dr. Hunt as a result of their contributions to public health. She has been elected a member of the prestigious Collegium Ramazzini, Carpi, Italy in 2011, and awarded the Blaise Pascal Chair of Biology 2013-15, at the Ecole Normale Supérieure, Paris.

Due to her unique profile spanning theoretical and experimental biology as well as medical/health issues such as breast and prostate cancer and endocrine disruptors, Dr. Soto is frequently called to serve as member of government-sponsored advisory panels dealing with public health issues, among them the US-National Academy of Sciences, Swiss National Science Foundation, US-EPA, EU-Environmental Agency. She has also been invited to testify before legislative bodies (US Congress, French Assamblee Nationale, etc).

Her research has been funded by the US National Science Foundation, the US-National Cancer Institute, the US EPA, the Susan G. Komen Foundation, the US-National Institute of Environmental Health Sciences, the Avon Foundation and the UK Medical Research Council.

Selected publications: a) Soto AM, Longo G, Montévil M, Sonnenschein C. The biological default state of cell proliferation with variation and motility, a fundamental principle for a theory of organisms. Prog Biophys Mol Biol. 2016;122:16-23; b) Soto AM, Longo G, Miquel PA, Montevil M, Mossio M, Perret N, Pocheville A, Sonnenschein C. Toward a theory of organisms: Three founding principles in search of a useful integration. Prog Biophys Mol Biol. 2016;122:77-82; c) Sonnenschein C, Soto AM. Carcinogenesis explained within the context of a theory of organisms. Prog Biophys Mol Biol. 2016;122:70-76; d) Montévil M, Speroni L, Sonnenschein C, Soto AM. Modeling mammary organogenesis from biological first principles: Cells and their physical constraints. Prog Biophys Mol Biol. 2016;122:58-69; e) Longo G, Montévil M, Sonnenschein C, Soto AM. In search of principles for a Theory of Organisms. J Biosci. 2015;40:955-68.

Professor at Tufts University School of Medicine

Carlos Sonnenschein

Carlos Sonnenschein is a Professor at Tufts University School of Medicine, a Corresponding Member at the Centre Cavaillès, Ecole Normale Supérieure (ENS), Paris, France, and a Fellow at the Institute of Advanced Studies-at-Nantes, France. For over four decades, his research centered on a) the control of cell proliferation by estrogens and androgens, b) the impact of endocrine disruptors on organogenesis and the reproductive function and c) carcinogenesis during early development and adult life and, specifically, on the role of stroma/epithelial interactions on rat and breast carcinogenesis.

In the early 1970s, Dr. Sonnenschein established and characterized the first mammalian estrogen-target cell. In the late 1980s, in partnership with Dr. Ana M. Soto, they identified estrogenic substances shedding from plastics and developed two in vitro bioassays that reliably identify synthetic estrogens and androgens (E-SCREEN and A-SCREEN, respectively); they are now used to detect natural and synthetic estrogenic and anti-androgenic compounds. He has served in national and international panels dealing with environmental sciences. Drs. Patricia Hunt (Washington State University), Sonnenschein and Soto shared the 2012 Jacoh Heskel Gabbay Price awarded by Brandeis University in recognition of their contributions in Medicine and Biotechnology.

In 1999, Drs. Sonnenschein and Soto co-authored a book entitled THE SOCIETY OF CELLS (Bios/Springer/Taylor & Francis) now translated into French (2006) and Spanish (2017). In it, briefly, they concluded that a) the default state of all cells is proliferation, and that b) sporadic cancers (over 95% of clinical cases) are anchored at the tissue level of biological organization. These are the core premises of their tissue organization field theory of carcinogenesis and metastases (TOFT). As reflected in scholarly and lay publications, the TOFT is increasingly accepted by the cancer research and secular communities as the theory that more reliably explain cancers under an evolutionary relevant perspective. In addition, Drs Sonnenschein and Soto have defined cancer as “development gone awry” and, accordingly, classified neoplasia as 1) sporadic, and 2) inborn errors of development, which in turn, can be either a) inherited, or b) induced. Dr. Sonnenschein teaches a graduate course at Tufts entitled “From the Cell to Cancer”.

Continuing their long-term partnership, Drs. Sonnenschein and Soto have also studied endocrinological and biophysical determinants of morphogenesis. Also, at the Centre Cavailles, ENS in Paris, they have been exploring the theoretical implications of TOFT within biology at large in the context of an ambitious theory of organisms. Dr. Sonnenschein continues to give seminars and lectures at colleges, universities and research institutes in the US, Europe, Asia and Latin America.

Ref. Sonnenschein C & Soto AM (2017) Why is it that despite signed capitulations the war on cancer is still on? ORGANISMS DOI: 10.13133/2532-5876_1.9.

Directeur de Recherche (DRE) CNRS at Centre Interdisciplinaire Cavaillès

Giuseppe Longo

Giuseppe Longo is Directeur de Recherche (DRE) CNRS at Centre Interdisciplinaire Cavaillès, (République des Savoirs, Collège de France et l’Ecole Normale Supérieure, Paris) and Adjunct Professor, Department of Integrative Physiology and Pathobiology, Tufts University School of Medicine, Boston Tufts University, Boston. He is a former Professor of Mathematical Logic and, later, of Computer Science at the University of Pisa. He spent 3 years in the USA (Berkeley, M.I.T., Carnegie Mellon) as researcher and Visiting Professor, in addition to several months visits in Oxford and Utrecht. He is a member of the Academia Europea since 1992. GL worked in Mathematical Logic and at various applications of Mathematical Logic to Computer Science.

Longo (co-)authored more than 100 papers and a book, with A. Asperti, on Categories, Types and Structures (M.I.T. Press, 1991) and is founder and former director (1990-2015) of Mathematical Structures in Computer Science, a leading scientific journal of the Cambridge U.P.. In this century, he extended his research interests and work to the Epistemology of Mathematics and Theoretical Biology. Bailly and Longo’s book, Mathematics and the natural sciences: The Physical Singularity of Life (Hermann, Paris, 2006; Imperial College Press, London, 2011) proposes a novel approach to cross-foundational analyses in Mathematics, Physics and Biology. Its consequences for more specific theorizing in Biology are in a joint book with Maël Montévil, Perspectives on Organisms: Biological Time, Symmetries and Singularities (Springer, Berlin, 2014). With A. Soto and D. Noble, Longo edited (and co-authored six papers) of a 2016 special issue of Prog Biophys Mol Biol, From the century of the genome to the century of the organism: New theoretical approaches. He currently directs a research project at IEA-Nantes (2014-20) on the concept of law, in human and natural sciences:  http://www.iea-nantes.fr/rtefiles/File/projet-giuseppe-longo-2014.pdf

 

CV Download here » Giuseppe Longo

Professore Ordinario di Biologia Applicata

Arturo Bevilacqua

RUOLI E INCARICHI
Titolare del corso di Biologia, corso di laurea triennale in Psicologia e Processi Sociali (9 cfu)
Titolare del modulo di Biologia Applicata, corso integrato di Scienze Biochimiche e Biologiche, corso di laurea triennale in Tecniche della prevenzione nell’ambiente e nei luoghi di lavoro (abilitante alla professione sanitaria di Tecnico della prevenzione nell’ambiente e nei luoghi di lavoro) (3 cfu).
Titolare del modulo di Biologia Applicata, corso integrato di Basi del funzionamento cellulare, corso di laurea triennale in Tecniche di laboratorio biomedico (abilitante alla professione sanitaria di Tecnico di laboratorio biomedico) (3 cfu).
Docente del Dottorato in Neuroscienze del Comportamento, curriculum di Psicobiologia e Psicofarmacologia.
INTERESSI DI RICERCA
1) Dipendenza della plasticità neuronale e delle capacità di apprendimento del mammifero adulto dai processi normali e patologici regolati da ligandi-recettori e il loro controllo trascrizionale/traduzionale;
2) associazione di polimorfismi allelici per geni di sistemi neurotrasmettitoriali e ormonali al disturbo ossessivo-compulsivo, al perfezionismo, alla schizofrenia, al transessualismo;
3) meccanismi regolativi dell’ovogenesi e dello sviluppo preimpianto del mammifero;
4) meccanismi molecolari dell’invecchiamento cellulare associato a patologie psichiatriche.
Pubblicazioni:

Fiorenza, M.T., Torcia, S., Canterini, S., Bevilacqua, A., Narducci, M.G., Ragone, G., Croce, C.M., Russo, G. and Mangia, F. (2008). TCL1 promotes blastomere proliferation through nuclear transfer but not direct phosphorylation, of AKT/PKB in early mouse embryos. Cell Death and Differentiation 15; 420-422.

Di Nocera, F. and Bevilacqua, A. (2011). Lo sviluppo del perfezionismo tra determinanti genetiche e apprendimento. In: Lombardo C., Violani C. Quando “perfetto” non è abbastanza. Conseguenze negative del perfezionismo. LED, Milano, 27-41.

Trabalza, A., Colazingari, S., Sgobio, C. and Bevilacqua, A. (2012). Contextual learning increases dendrite complexity and EphrinB2 levels in hippocampal mouse neurons. Behavioural Brain Research 227; 175–183, DOI 10.1016/j.bbr.2011.11.008.

Vellani, E., Mamazza, L., Colasante, A., Treglia, M., Minasi, M.G., Greco, A., Greco, E. and Bevilacqua, A. (2012). Effetto dell’ansia di stato e di tratto sulla qualità del liquido seminale in pazienti programmati per la fecondazione in vitro. Modelli per la Mente 1; 41-49.

Vellani, E., Colasante, A., Mamazza, L., Minasi, M.G., Greco, A., Greco, E. and Bevilacqua, A. (2013). Association of state and trait anxiety to semen quality of in vitro fertilization patients. A controlled study. Fertility and Sterility 99(6): 1565-1572.e2, DOI 10.1016/j.fertnstert.2013.01.098.

Colazingari, S., Treglia, M., Najjar, R. and Bevilacqua, A. (2013). The combined therapy Myo-inositol plus D-chiro-inositol, rather than D-chiro-inositol, is able to improve IVF outcomes: Results from a randomized controlled trial. Archives of Gynecology and Obstetrics 288(6): 1405-1411, DOI 10.1007/s00404-013-2855-3.

Colazingari, S., Fiorenza, M.T., Carlomagno. G., Najjar, R. and Bevilacqua, A. (2014). Improvement of mouse embryo quality by myo-inositol supplementation of IVF media. Journal of Assisted Reproduction and Genetics 31(4): 463-469. DOI 10.1007/s10815-014-0188-1.

Bevilacqua, A. (2014). La fisiologia sale in cattedra: il myo-inositolo nel laboratorio di PMA. Atti del Congresso Nazionale SIFIOG, Roma, 30-31 maggio 2014, Edizioni Minerva Medica (TO), 6-10. ISBN: 978-88-7711-809-7.

Di Nocera, F., Colazingari, S., Trabalza, A., Mamazza, L. and Bevilacqua, A. (2014). Association of TPH2 and dopamine receptor gene polymorphisms with obsessive-compulsive symptoms and perfectionism in healthy subjects. Psychiatry Research 220: 1172–1173. DOI 10.1016/psychres.2014.09.015.

Bevilacqua, A., Carlomagno, G., Gerli, S., Montanino Oliva, M., Devroey, P., Lanzone, L., Soulage, C., Facchinetti, F., Di Renzo, G.C., Bizzarri, M., Hod, M., Cavalli, P., D’Anna, R., Benvenga, S., Chiu, T.T. and Kamenov, Z.A. (2015). Results from the International Consensus Conference on Myo-inositol and D-chiro-inositol in Obstetrics and Gynecology – Assisted Reproduction Technology. Gynecological Endocrinology 1-6: 2 june. DOI: 10.3109/09513590.2015.1006616.

Bevilacqua, A. e Borzi, M. (2015). Neurobiologia della dipendenza sessuale. In Cantelmi T., Lambiase E. Schiavi del sesso. Sesso patologico, eccessi, dipendenza e tecnosex. Alpes (Roma), 97-126

Bevilacqua, A. (2015). Migliore è il terreno migliori sono gli embrioni. Atti del Congresso Nazionale SIFIOG, Roma, 18-19 giugno 2015, Edizioni Minerva Medica (TO), in stampa.

Facchinetti, F., Bizzarri, M., Benvenga, S., D’Anna, R., Lanzone, L., Soulage, C., Di Renzo, G.C., Hod, M., Cavalli, P., Chiu, T.T., Kamenov, Z., Bevilacqua, A., Carlomagno, G., Gerlig, S., Montanino Oliva, M. and Devroey, P. (2015). Results from the International Consensus Conference on Myo-inositol and D-chiro-inositol in Obstetrics and Gynecology: the link between metabolic syndrome and PCOS. European Journal of Obstetrics & Gynecology and Reproductive Biology 195: 72-6. DOI: 10.1016/j.ejogrb.2015.09.024

Bevilacqua, A. and Bizzarri, M. (2016).  Physiological role and clinical utility of Inositols in Polycystic Ovary Syndrome. Best Practice & Research Clinical Obstetrics & Gynecology. DOI: 10.1016/j.bpobgyn.2016.03.007.

Bizzarri M., Cucina, A., Dinicola,S., Harrath, A.H., Alwasel, S.H., Unfer, V. and Bevilacqua, A. (2016). Does myo-inositol effect on PCOS follicles involve cytoskeleton regulation? Medical Hypotheses 91: 1–5. DOI: 10.1016/j.mehy.2016.03.014.

Bizzarri M, Fuso A, Dinicola S, Cucina A, and Bevilacqua A. (2016). Pharmacodynamics and pharmacokinetics of inositol(s) in health and disease. Expert Opinion On Drug Metabolism and Toxicology Jul 14:1-16. DOI: 10.1080/17425255.2016.1206887.

Kuşcu N, Bizzarri M and Bevilacqua A. (2016). Myo-Inositol Safety in Pregnancy: From Preimplantation Development to Newborn Animals. International Journal of Endocrinology Vol. 2016, Article ID 2413857, 10 pages. DOI: 10.1155/2016/2413857.

Bizzarri, M., Dinicola, S., Bevilacqua, A. and Cucina, A. (2016). Broad spectrum anti-cancer activity of myo-inositol and inositol hexakisphosphate. International Journal of Endocrinology. Vol. 2016. Article ID 5616807, 14 pages. DOI: 10.1155/2016/5616807.

Francesconi, M., Minichino, A., Carriòn, R., Delle Chiaie, R., Bevilacqua, A., Parisi, M., Rullo, S., Bersani, F.S., Biondi, M. and Cadenhead, K.S. (2016). Theory of Mind as a mediator variable between Neurocognition and Functioning in young individuals in treatment with secondary services for non-psychotic disorders. Psychiatry ResearchOct 6; 246: 415-420. doi: 10.1016/j.psychres.2016.09.057.

Bevilacqua, A., Amicarelli, F. e Fiorenza, M.T. (2016). Basi biologiche dell’attività psichica. Seconda parte: Genetica. Piccin Nuova Libraria (PD).

Francesconi, M., Minichino, A., Carriòn, R., Delle Chiaie, R., Bersani, F.S., Bevilacqua, A., Parisi, M., Rullo, S., Biondi, M. and Cadenhead, K.S. (2016). Psychosis prediction in secondary mental health services. A broad, comprehensive approach to the “at risk mental state” syndrome. European Psychiatry40: 96–104. Published online: December 16, 2016. doi: 10.1016/j.eurpsy.2016.09.002.

Minichino A, Francesconi M, Carriòn R, Delle Chiaie R, Bersani FS, Bevilacqua A, Parisi M, Rullo S, Biondi M, Cadenhead KS. (2016). Prediction of functional outcome in young patients with a recent-onset psychiatric disorder: Beyond the traditional diagnostic classification system. Schizophrenia Research. doi: 10.1016/j.schres.2016.12.019.

Francesconi M, Minichino A, Carriòn R, Delle Chiaie R, Bersani FS, Bevilacqua A, Parisi M, Rullo S, Biondi M, Cadenhead KS. (2017). From neurological soft signs to functional outcome in young individuals in treatment with secondary services for non-psychotic disorders: a path analysis. Psychological Medicine,. doi: 10.1017/S0033291716003056.

Aggregate Professor

Giulia Ricci

EDUCATION

  • 1989: classical studies achieved with full marks
  • 1995: Master Degree in Biology at the University of Rome “Sapienza” with full marks;
  • 2000: PhD in Cellular Science and Technology at the University of Rome “Sapienza;
  • 2004: Specialization degree in Clinical Pathology at the University of Rome “Sapienza”.

POSTDOCTORAL TRAINING

  • 2001: winning post-doctoral research fellowship at the University of Rome “Sapienza” at the Dept. of Histology and Medical Embryology.
  • 2001: attended the summer course “Embryology: New concepts and techniques” at the “Marine Biological Laboratory” in Woods Hole (MA; USA) as winner of the “A. Monroy Foundation” scholarship.

ACADEMIC APPOINTMENTS

  • In February 2002 Dr. Giulia Ricci turned out as winner of the public competition to award a position of Researcher in Histology and Embryology (BIO 17) at the School of Medicine of The Second University of Naples;
  • Since May 2002 Dr. Giulia Ricci has been in charge as Researcher in Histology and Embryology (BIO-17) at the Department of Experimental Medicine of the School of Medicine of the Second University of Naples;
  • Since 2002 Dr. Giulia Ricci has been in charge as the coordinator of the Histology and Embryology course at the School of Medicine of the Second University of Naples. She has been in charge, also, as professor of Histology and Embryology in the same Academic Course
  • From 2005 to 2009 Dr. Giulia Ricci taught Histology and Embryology also to Laboratory Technicians and to Biotechnologists of the Second University of Naples.

AWARDS AND HONORS

  • 2014: National Scientific Qualification as Associate Professor in “Human Anatomy” Section (05H1);
  • 2014: National Scientific Qualification as Associate Professor in “Anatomy and Cytology ” Section (05B2).

UNIVERSITY COMMITTEE ASSIGNMENTS

  • Since 2011 Dr. Giulia Ricci has been in charge as Tutor and as part of the faculty of the School of Doctorate in Morphogenesis and Tissue Engineering of the University of Rome. “Sapienza”. She has been tutor of the following PhD thesis:

-“Expression and functional role of R-Spondin-1 and its molecular pathway during the gonadal embryonic development of both sexes” (XXVII cycle).

-“C-Met proto-oncogene in testicular germ cell tumours” (XXXcycle).

  • Since 2011 Dr. Giulia Ricci has been in charge as Responsible of Teaching and Research activity (RADoR) at the Laboratory of Histology and Embryology of the Department of Experimental Medicine of the Second University of Naples.
  • Since 2012 Dr. Giulia Ricci has been in charge as Professor of Embryology at the Master Course entitled “Prenatal Diagnosis and Fetal Pathology” at the School of Medicine of the University of Rome “Sapienza”.
  • Since 2013 Dr. Giulia Ricci has been in charge as Scientific Responsible of the Electron Microscopy facility of the Department of Experimental Medicine of the Second University of Naples;

MAJOR COMMITTEE ASSIGNMENTS/PROFESSIONAL SERVICE

  • Meetings

Lecturer at the following National Meeting

National Congress on “Anomalie della differenziazione sessuale: inquadramento diagnostico e approccio terapeutico”, held in Rome from 25th to 26th October 2003. Title of the lecture: “Embriologia dello sviluppo sessuale”.

National Meeting on “Il percorso diagnostico multidisciplinare del feto con patologia genetico-malformativa. Focus: displasie scheletriche e patologie cerebrali”, held in Genova from 26th to 27th February 2015. Title of the lectures: “Lo sviluppo del Sistema Nervoso”, and “Lo sviluppo della faccia e del massiccio mediano”.

National Meeting on “Il percorso diagnostico multidisciplinare del feto con patologia genetico-malformativa. Anomalia del sistema genito-urinario: dalla genetica alla clinica”, held in Rome from 12th to 13th May 2016. Title of the lecture: “Lo sviluppo dell’Apparato Genitale”.

Participant

From 1998 to nowadays Dr. Giulia Ricci contributed with abstracts or oral presentations to 25 National Congresses and 15 International Meetings.

  • Editorial board member of the following journals:

International Scholarly Research Network – Anatomy section

Dataset Papers in Biology – Anatomy section

Asian Pacific Journal of Reproduction

Advances in Andrology

Journal of Andrology, Gynecology and Ostetrics

Biomedicines

  • Review editor of the following journals:

“Stem Cell Research” section of “Frontiers in Genetics”, “Frontiers in Oncology”, “Frontiers in Bioengineering and Biotechnology”, “Frontiers in Cell and Developmental Biology”

“Experimental Endocrinology” section of “Frontiers in Endocrinology”

“Cellular Biochemistry” section of “Frontiers in Chemistry” Frontiers in Endocrinology

  • Reviewer of the following journals:

PLOSone

General and Comparative Endocrinology

Reproductive Biology and Endocrinology

Pharmaceutical Science

Andrologia

Journal of Endocrinology

Human Reproduction

Asian Journal of Andrology

Advances in Andrology

International Journal of Biological Science

International Journal of Andrology

International Journal of Fertility and Sterility

International Journal of of Cell Biology

International Journal Molecular Science

Biotechnic & Histochemistry

Endocrine

  • Lead Guest editor of the following special issue:

“New aspects of the Hepatocyte Growth Factor/c-Met System” published on “biomedicines” in 2015.

Website: http://www.mdpi.com/journal/biomedicines/special_issues/Hepatocyte-Growth-Factor

RESEARCH GRANTS

Research Unit responsible

  • 2001: “Progetto Giovani Ricercatori” financed by MURST.
  • 2014: Workpackage responsible in the ASI project (N: 2014-018-R.0) entitled “”SHAPE- A New Theoretical Framework of the Microgravity-Cell Interaction”.

Participant

  • 2003: PRIN, “Espressione di c-Myc e p53 nel diabete autoimmune di tipo 1. Un possibile ruolo eziopatogenetico”, coordinated by Prof. Gianpaolo Papaccio
  • 2004: PRIN, “Isolamento, coltura, caratterizzazione e differenziamentoosteogenico di cellule staminali provenienti da polpa di denti permanenti e decidui” coordiante by Prof. Fernando Gombos.
  • 2008: PRIN, “Controllo del sistema degli endocannabinoidi sull’attività riproduttiva in anfibi e mammiferi”, coordinated by Prof. Riccardo Pierantoni.
  • 2010-2011: PRIN, “Cellule staminali “mesenchimali” come progenitori e come microambiente: meccanismi fondamentali, ruolo in patologia e traduzione terapeutica”, coordinated by Prof. Paolo Bianco.
  • 2012: PON01_02834 “Prometeo-Progettazione e Sviluppo di piattaforme tecnologiche innovative e Ottimizzazione di PROcessi per applicazioni in MEdicina rigenerativa in ambito oromaxillofacciale, emaTologico, nEurologico e cardiOlogico”, coordinated by Prof. Gianpaolo Papaccio

Main scientific fields of interest

  • Reproductive Biology:
  • Growth factors involved in male and female gonad physiology
  • Embryonic development and postnatal differentiation of the reproductive organs.
  • Endocannabinoid system in the reproductive tract.
  • Cancer cell behavior:
  • Cytoskeleton and adhesion molecule modifications in normal and cancer cell.
  • Growth factors and signaling pathways involved in carcinogenesis
  • Effect of the microgravity on cancer cell physiology.
  • Cell Biology
  • Cell differentiation and regenerative medicine

BYBLIOMETRIC INDEXES

H Index: 17

number of publications: 51

Number of citations: 839

Scopus Author ID: 9249126500

http://orcid.org/0000-0002-2199-170X

BOOK CHAPTERS

2011: Dr. Giulia Ricci wrote the chapter entitled “Sviluppo dell’apparato genitale” in the book entitled “Embriologia Umana”, edited by Idelson-Gnocchi, and dedicated to the students of the School of Medicine.

Chiara Simeoni

In order to attain the specific objectives of an international higher education at the University of Nice-Sophia Antinopolis, I have invested my competences for developing innovative teach ng projects in Mathematical Modelling for the Applied Sciences, which is becoming an essential tool in various domains of engineering and technology especially for its inherent multidisciplinary approach.

CV Download here » Chiara Simeoni CV

corrado mascia

Associate Professor Mathematics Department G.Castelnuovo

Corrado Mascia

Corrado Mascia is an Associate Professor (MAT/05 – Analysis) at the Mathematics Department “G.Castelnuovo” Sapienza, University of Rome.

Personal data
Degrees: Laurea in Mathematics (Sapienza, University of Rome, 1992)
PhD in Mathematics (Sapienza, University of Rome, 1997)
Current position: Associate Professor (MAT/05) since 01/01/2005.
Previous position: Researcher (MAT/05) from 18/07/1996 until 31/12/2004.

Research interests
Research area: Partial differential equations (hyperbolic and parabolic type).

Teaching activity
Given Courses: Calculus, Mathematical Analysis, Differential Equations
for mathematics and physics curricula.

Download CV »Corrado Mascia CV

Professore Ordinario di Patologia Clinica

Roberto Verna

INCARICHI ATTUALI, ANCHE CON COMPETENZE AMMINISTRATIVE

Direttore del Centro di Ricerca per la Medicina e il Management dello Sport della Sapienza Università di Roma dal 1.1. 2012.

Direttore del Master di Secondo Livello in Ricerca clinica: metodologia, farmacovigilanza, aspetti legali e regolamentari.

President, World Pathology Foundation

President incoming, World Association of Societies of Pathology and Laboratory Medicine (WASPaLM)

Rappresentante all’Organizzazione Mondiale della Sanità della World Association of Societies of Pathology and Laboratory Medicine (WASPaLM)

Past President, Società Italiana di Patologia Clinica e Medicina di Laboratorio – SIPMeL

Membro del Consiglio Direttivo della Federazione Italiana delle Società di Medicina di Laboratorio (FISMeLab)

Membro del Consiglio Direttivo della Federazione Italiana delle Società Medico Scientifiche (FISM)

Membro del Comitato Esecutivo del Comitato Internazionale delle Organizzazioni delle Scienze Mediche    -CIOMS

AREE DI COMPETENZA SCIENTIFICA

Patologia Clinica e Diagnostica di laboratorio, Disendocrinie e dismetabolismi, Scienza dell’alimentazione, Fisiopatologia delle attività sportive, Invecchiamento, Osteoporosi, Biotecnologie.

ESPERIENZE NELLA GESTIONE DI ENTI ED ORGANISMI DI RICERCA E DI UNIVERSITÀ

INCARICHI SCIENTIFICI ED ACCADEMICI, DEI QUALI NUMEROSI CON COMPETENZE AMMINISTRATIVE

Membro della Giunta del Collegio dei Professori Universitari di Patologia Clinica.

2011-2015 Presidente, Associazione Italiana di Patologia Clinica e Medicina Molecolare e Presidente del Comitato Scientifico dell’Associazione dal 1996

2007-2015. Membro del Direttivo Internazionale della World Association of Societies of Pathology and Laboratory Medicine (WASPaLM) – Direttore dell’Area Europa, Medio Oriente, Nord Africa – Rappresentante presso l’Organizzazione Mondiale della Sanità.

1996-2015, Direttore Responsabile e Direttore Scientifico del “Journal of  Molecular and Clinical Pathology – Il Patologo Clinico”.

2005-2011, Direttore del Centro di Ricerca per la Sperimentazione Clinica dell’Università degli Studi di Roma La Sapienza

2002-2012, Direttore del Master di Secondo Livello in Sperimentazione Clinica dell’Università degli Studi di Roma La Sapienza

2010, Direttore del Master di Primo Livello per Dirigente e Agente Sportivo 2010 dell’Università degli Studi di Roma La Sapienza

Esperto presso il Consiglio Superiore di Sanità, nominato con Decreto del  Ministro della Sanità del  4.9.2000

Membro della Commissione Nazionale per la vigilanza ed il controllo sul doping e per la tutela della salute nelle attività sportive, nominato con decreto congiunto del Ministro della Sanità e del Ministro per i beni e le attività culturali in base alla legge 376/2000 per il periodo 2000-2005

Coordinatore della Commissione per i campi in erba artificiale presso il Ministero della Salute, nominato con DM del 9.11.05. La Commissione è stata sciolta nel 2007.

Membro della Commissione per la balneazione, presso il Ministero della Sanità. 2001

Direttore del Master di Primo Livello in Medicina e Fisiologia dello Sport, Università di Roma La Sapienza, anno accademico 2007-2008

Direttore del Master di Primo Livello in Organizzazione, Promozione, gestione e Tutela della Salute delle Attività Sportive, anno accademico 2008-2009.

Direttore del Corso di Alta Formazione in Attività Sportive e Tutela della Salute, Università di Roma La Sapienza, A.A. 2009-2010.

Direttore del Corso di Alta Formazione in Sperimentazione Clinica, Università di Roma La Sapienza A.A. 2009-2010

Rappresentante del Ministero della Salute nella Commissione per i campi in erba sintetica istituita dalla Federazione Italiana Giuoco Calcio, fino al 2007.

INCARICHI SCIENTIFICI ED ACCADEMICI TRASCORSI, ALCUNI CON COMPETENZE AMMINISTRATIVE (SEGNATI CON *)

1984 – Membro del Comitato Direttivo dell’European Membrane Club (EMC)

1985 – Esperto del Ministero Affari Esteri per la concessione di Borse di Studio all’estero.

1987 – Esperto della Commissione per la revisione della Farmacopea Ufficiale.

1986 -95 *Direttore della Scuola di Specializzazione in Patologia Clinica, Università degli Studi, L’Aquila.

1987 -95 *Presidente del Comitato Universitario per lo Sport, Università degli Studi, L’Aquila.

1988 -95 *Coordinatore del Dottorato di Ricerca in Scienze Endocrinologiche e Metaboliche, Università degli Studi di L’Aquila.

1989 – 91 *Direttore dell’Istituto Superiore di Educazione Fisica, L’Aquila.

1989 – 91    *Membro del Consiglio di Amministrazione dell’ISEF, L’Aquila.

1991 – 95 *Direttore della Scuola Diretta a Fini Speciali per Tecnici di Laboratorio Biomedico, Università degli Studi di L’Aquila.

1993 – 95 Presidente del Collegio dei Direttori delle Scuole di Specializzazione e Dirette a Fini Speciali, Università degli Studi, L’Aquila.

1994 – 95 *Presidente del corso di Diploma Universitario per Tecnici di Lab. Biomedico, Università degli Studi, L’Aquila.

1988 – Membro del Comitato Scientifico della Società Italiana di Medicina di Laboratorio.

1989 – 98 *Membro del Comitato di Progetto del Progetto Finalizzato CNR Invecchiamento.

1996 – 98 Membro del Consiglio Scientifico dell’Ass. Italiana per la Lotta all’Artrosi ed all’osteoporosi (AILA).

    1.   *Membro del Consiglio Direttivo della Società Italiana per l’Osteoporosi (SIOP).
  1. *Presidente della Fondazione per l’Avanzamento della Ricerca in Medicina

Molecolare – FARMM onlus.

CARRIERA ACCADEMICA

1966 – Maturità Scientifica, Liceo Scientifico Statale Plinio Seniore, Roma

1971 – Laurea in Scienze Biologiche, Università di Roma, 21 luglio 1973, 110 e lode.

1974 – Specializzazione in Scienza dell’Alimentazione, 26 luglio 1974, Università di Roma, 70 e lode (n.1063).

1978 – Laurea in Medicina e Chirurgia, Università di Roma, 14 giugno 1978, 110 e lode.

1978 – Abilitazione alla professione medica.

1979 – Specializzazione in Patologia Generale, 23 giugno 1979, Università di Roma, 70 e lode (n.37917).

1982 – Specializzazione in Endocrinologia, 2 luglio 1982, Università di Roma, 70 e lode (n.36565).

1973-75 – Borsista Ministero P.I. presso l’Istituto di Fisiologia Generale, Università degli Studi di

    Roma.

1975-81 – Contrattista presso l’Istituto di Patologia Generale, Università degli Studi di Roma.

1981-86 – Ricercatore (gruppo 70) presso l’Istituto di Patologia Generale, Università degli Studi di

Roma.

1986 – Vincitore del concorso a professore di ruolo prima fascia gruppo 256, prende servizio il 6 giugno presso l’Università degli Studi di L’Aquila quale Professore Straordinario di Chimica e Microscopia Clinica

1988 – Opzione per la disciplina Patologia Clinica (Settore Scientifico Disciplinare F04B)

1989 – Nomina a Professore Ordinario di Patologia Clinica

1995 – Chiamato dalla Facoltà di Medicina dell’Università di Roma “La Sapienza” a ricoprire per trasferimento la Cattedra di Patologia Clinica, prende servizio in data 1.11.95, con afferenza al Dipartimento di Medicina Sperimentale e Patologia.

ATTIVITÀ DI RICERCA ALL’ESTERO

1981 – Visiting Scientist presso il Laboratory of Molecular Biology, National Cancer Institute, N.I.H., Bethesda MD – USA.

1983 – Visiting Scientist presso I.N.S.E.R.M., Unité de Pharmacologie Vasculaire et Renale, Hopital Necker, Paris – France.

1988 – Visiting Scientist presso il National Institute of Diabetes Digestive and Kidney   

Diseases, N.I.H., Bethesda MD – USA.

INCARICHI PROFESSIONALI

1975-1977 Direttore dei laboratori dell’Azienda Farmaceutica Istituto Biochimico Italiano sud, sede di Aprilia

1977-1979 Consulente dell’Azienda Farmaceutica Ravasini Organon, sede di Pomezia

1995 – 98 Perito del GIP del Tribunale di Trento nel procedimento penale 358/94, concernente il controllo della contaminazione di plasma ed emoderivati da parte di virus HIV1, HIV2, HBV, HCV, PvB19, CMV (cinque incarichi peritali successivi che hanno riguardato l’analisi di circa 2.500 pezzi, campionati da un totale di 180.000 sacche di plasma, 60.000 kg di intermedi di lavorazione, oltre 100.000 flaconi di prodotti finiti).

1997 Perito di parte della Chiron Corporation nel procedimento Chiron vs. Murex innanzi al Tribunale di Roma.

1997 – 02   Membro della Commissione medica dell’INPDAI per l’accertamento dell’invalidità.

Dal 2007- Consulente della SS Lazio Calcio per la Valutazione Metabolica ed il trattamento Nutrizionale degli Atleti della prima squadra dalla stagione 2006-2007 a tutt’oggi. Con la Lazio, è vincitore della Coppa Italia 2009 e della Supercoppa Italiana 2009.

2009 Consulente dell’Udinese Calcio per la Valutazione Metabolica ed il trattamento Nutrizionale degli Atleti della Società, stagione 2008-2009.

2010 Consulente del Parma FC per la Valutazione Metabolica ed il trattamento Nutrizionale degli Atleti della Società, stagione 2010-2011

Consulente dell’Arma dei Carabinieri e del Gruppo Sportivo Fiamme Gialle della Guardia di Finanza per la valutazione metabolica e nutrizionale e la formazione antidoping dei loro atleti.

INCARICHI ASSISTENZIALI

1981 – 86 Assistente c/o Istituto di Patologia Generale, Servizio di Patologia Molecolare ed Ultrastrutturale, Università degli Studi di Roma (Primario Prof. F.G. Caramia).

2000 –       Nomina, da parte del Consiglio di Dipartimento e del Consiglio di Facoltà, a Direttore del Servizio Speciale di Analisi Chimico Cliniche e Radioimmunologiche del Policlinico Umberto I°.

EDITORIAL BOARDS

Direttore Scientifico della Rivista Journal of Molecular and Clinical Pathology – Il Patologo Clinico

Membro del Comitato Scientifico delle Riviste:

  Progressi in Medicina di Laboratorio

  Tribuna Biologica e Medica

  European Journal of Laboratory Medicine

  Italian Journal of Sport Sciences

ATTIVITÀ DIDATTICA

Titolare del Corso di Chimica e Microscopia Clinica dal 1986 al 1989/90.

Titolare del Corso di Patologia Clinica dal 1990 ad oggi.

Affidamento del Corso di Citopatologia (1990/91)

Titolare del corso di Patologia Clinica nelle seguenti Scuole di Specializzazione della Facoltà di

Medicina di L’Aquila: Medicina Interna; Ostetricia e Ginecologia; Allergologia;  Gastroenterologia; Chirurgia Generale; Chirurgia Digestiva; Dermatologia; Neurologia; Endocrinologia; Oncologia; Pediatria.

Titolare degli insegnamenti di Patologia Clinica e di Immunoematologia nel Diploma Universitario di Scienze Infermieristiche.

Titolare di numerosi insegnamenti nella Scuola di Specializzazione in Patologia Clinica e nella

Scuola Diretta a Fini Speciali per Tecnici di Laboratorio Biomedico.

Docente di Biologia Generale presso l’ISEF di L’Aquila dal 1978 al 1981 presso la sede

decentrata di Cagliari e dal 1981 al 1988 presso la sede decentrata di Cassino.

Docente di Farmacologia applicata allo Sport presso l’ISEF di L’Aquila, sede centrale, dal 1988 al 1992.

Titolare dell’insegnamento di Patologia Clinica nel Corso di Laurea in Medicina, nella scuola di Specializzazione in Patologia Clinica II ed in numerose altre scuole di Specializzazione, nel D.U. per tecnici di Laboratorio Biomedico, nel Corso di Laurea per Tecnico di Laboratorio Biomedico, Università degli Studi di Roma “La Sapienza”, dal 1 novembre 1995 ad oggi.

Coordinatore del I semestre del IV anno del CCL “C” dall’A.A. 1996/97. Coordinatore del Corso Integrato di Semeiotica e Metodologia Clinica compresa la Medicina di Laboratorio, per l’A.A. 1997/98, 1998/99, 1999/2000.

Coordinatore dei seminari clinici del III, IV e V anno del CCL “C”, per l’A.A. 1997/98.

Coordinatore del II semestre del III  anno del CCL “C” dall’A.A. 1999.

PRINCIPALI LINEE DI RICERCA SVOLTE

1 – Fisiopatologia delle membrane plasmatiche e del trasporto transmembrana

2 – Fisiopatologia del metabolismo delle lipoproteine e dell’invecchiamento

3 – Fisiopatologia e patologia molecolare dei recettori e delle molecole di trasmissione

4 – Applicazione della biologia molecolare e delle biotecnologie alla diagnostica di laboratorio

5 – Patologia Clinica applicata alle Attività Sportive

E’ autore di 150 pubblicazioni sulle principali riviste internazionali e di 12 libri. Ha tenuto più di 30 letture su invito ai principali congressi.

ATTIVITA’ ORGANIZZATIVA

Organizza il Congresso Nazionale annuale dell’Associazione Italiana Patologi Clinici (che ha modificato il nome in Associazione Italiana di Patologia Clinica e Medicina Molecolare) dal 1995, presiedendone il Comitato Scientifico.

Ha organizzato i seguenti Congressi Internazionali curandone anche la Segreteria Scientifica:

Peptide hormones, biomembranes and cell growth. Roma, 1984

Genetic and phenotypic markers of tumors. Roma, 1984

Peptides and ion transport. L’Aquila, 1985

Advances in Biotechnology of  Membrane Ion Transport. Roma, 1988

Bioengineered Molecules: Basic and Clinical Aspects. Roma, 1989.

Membrane Technology. Roma, 1989.

Biotechnology of Cell Regulation. Siena, 1991.

Biotechnology Today. Roma, 1994.

Ha istituito, nell’Università di L’Aquila, la Scuola di Specializzazione in Patologia Clinica, prima in Italia, nel 1986.

Ha istituito, nell’Università di L’Aquila nel 1988, la Scuola Diretta a Fini Speciali per Tecnico di Laboratorio Biomedico e, successivamente, il Corso di Laurea Breve per Tecnici di Laboratorio Biomedico.

Ha istituito, nell’Università di Roma La Sapienza, nel 2002 il Master di Secondo Livello in Sperimentazione Clinica: nel 2005 il Master di Primo Livello in Medicina e Fisiologia della Sport.

Ha istituito, nell’Università di Roma La Sapienza, nel 2004, il Centro di Ricerca per la Sperimentazione Clinica

ELENCO DELLE PUBBLICAZIONI SCIENTIFICHE

1 – Tria E, Scapin S, Verna R. (1973). Ricerche sulla presenza di un attivatore della lipasi pancreatica in estratti della parete colecistica. Quaderni della Nutrizione,1971, XXXI, 31-45.

2 – Luly P and Verna R (1974). Stimulation of (Na/K)ATPase of rat liver plasma membranes by aminoacids.Bioch. Bioph. Acta. 367, 109-113.

3 – Luly P, Politi E, Verna R, Cocco C (1974). Permeabilità di cellule isolate ai nucleotidi adenilici. Boll. Chim. Farmac. 113, 428-430.

4 – Tria E, Luly P, Verna R, Cocco C (1974). Preparazione di membrane plasmatiche da cellule isolate di fegato e azione delle metilxantine sull’attività ATPasica. Arch. Fisiol., 71, 128-129.

5 – Leoni S, Luly P, Mangiantini MT, Spagnuolo S, Trentalance A and Verna R (1975). Hormone responsiveness of plasma membrane-bound enzymes in normal and regenerating rat liver. Bioch. Bioph. Acta 394, 317-322.

6 – Luly P and Verna R (1976). Comparative aspects of plasma membrane-bound enzymes in frog and rat liver. Int. J. Biochem. 7, 633-634.

7 – Frati L, D’Armiento M, Gulletta E, Verna R, Covelli I (1977). The control of epidermis proliferation by EGF. Relationship with cyclic nucleotides system. Pharmacol. Res. Comm. 9, 815-822

8 – Faggioni A, Fulvio E, Iezzi MT, Improta C, Modesti A, Torrisi MR and Verna R (1978). The mechanism of action of EGF. Synthesis of Bio-active insolubilized EGF. I.R.C.S. Medical Sci. 6,155.

9 – Lauro R, D’Armiento M, Lacerna F, Verna R, Caramia FG, Frati L (1978). Effetto della prazosina sul sistema del cAMP nell’aorta di ratti geneticamente ipertesi. In: Problemi e prospettive dell’ipertensione arteriosa, Bertelli et al. Eds. ESAM, 57-65.

10 – Frati L, De Vecchis L, D’Armiento M, Faggioni A, Fulvio E, Masciangelo R, Torrisi MR and Verna R (1979). The control of cell proliferation by Epidermal Growth Factor: relationship with cyclic nucleotides system. Chem. Oncol. 3, 172-176.

11 – Lacerna F, Verna R, Cannistrà FM (1979). Il Tinidazolo. Farmaci 3, 705-727.

12 – Verna R, Nardi P, Modesti M, Modesti A (1980). Inhibition of Na/K ATPase activity by  prostaglandins in rat liver plasma membranes. I.R.C.S. Medical Science 8, 292.

13 – D’Armiento M, Lacerna F, Lauro R, Modesti A, Verna R, Ceccarelli G (1980). Effect of Prazosyne on the cAMP system in the spontaneously hypertensive rats (SHR) aorta. Eur. J. Pharmacol. 65, 243-247.

14 – Verna R, Pappagallo S, Muraro R, Napolitano G, Benedetti M, Dondoli J (1981). Effetto dell’EGF sulla Na/K ATPasi in cellule HeLa. Chem. Oncol. vol. 3-4, 226.

15 – Verna R, Modesti A, Torrisi MR, Calandri C, Ciccone F, Isacchi G (1981). Anemie diseritropoietiche congenite (CDA): Studi ematochimici, cinetici, ultrastrutturali. In: apporto della ricerca di base al controllo della crescita neoplastica. Idelson, Napoli, 887-893.

16 – Verna R and Frati L (1982). Na/K ATPase and cell growth. A marker of neoplastic growth? In: Membranes and tumour growth, G.Galeotti ed., Elsevier- North Holland, 515-525

17 – Verna R and Frati L (1982). Na/K ATPase and Cell Growth. II: EGF modulates the enzymatic activity in cultured fibroblasts. Cytobios, 35: 181-186.

18 – Verna R, Muraro R, Sinibaldi P, Giganti MG and Frati L (1982). Protein Kinases and Na/K ATPase. A tool to evaluate the sensitivity of cells to protein hormones. Chemioterapia vol.1 n.6 395-401.

19 – Frati L, Cortesi E, Faggioni A, Martinotti S and Verna R (1982). Tumor markers: markers as expression of neoplastic progression and oncogenic markers. Atti del First International Symposium on advances in cancer treatment. Alghero, pp. 23-25.

20 – Verna R and Muraro R (1983). Essential hypertension: role of Na/K ATPase and relationship with the cyclic nucleotides system. Cellular and Molecular Biology, 27,1,93-102.

21 – Verna R, and Frati L (1983). Na/K ATPase and Cell Growth. I: Effect of EGF on the enzymatic   activity of chick embryo epidermis during the embryonal development. Int. J. Biochem. 15,1: 1-3.

22 – Verna R and Frati L (1983). Na/K ATPase and cell Growth. III: enzymatic activity in cultured and EGF stimulated Hela cells. Int. J. Biochem. 15, 2: 137-138.

23 – Verna R, Nardi P, Muraro R, Delfini R and Frati L (1983). Na/K ATPase and cell growth. IV: a metabolic marker of human brain tumors? J. Neurosurg. Sci. 27, 2, 77-82.

24 – Di Curzio B, Modesti M, Viceconte G, Viceconte GW, Modesti A, Verna R, Messinetti S (1983). Polipi gastrici. Minerva Dietologica e Gastroenterologica 29, 1-10.

25 – Verna R, Frati L and Garay R (1983). Effetto della somministrazione di antiblastici in vivo sui flussi cationici negli eritrociti. Chemioterapia vol. 2, 265-266.

26 – Verna R, D’Onofrio M, Pozzi D and Frati L  (1983). Inibizione da antiblastici della Na/K ATPasi di cellule tumorali in cultura. Chemioterapia vol. 2, 266-267.

27 – Diez J, Braquet P, Nazaret C, Hannaert P, Verna R and Garay R  (1983). The effects of cyclic nucleotides and eicosanoids on Na and K transport systems in human red cells and mouse macrophages. Advances in cyclic nucleotide and protein phosphorylation research, vol. 17, P. Greengard et al. Eds., Raven Press, NY pp. 621-630.

28 – Verna R, Favuzzi E, Nardi P, Milza PG, Agresta R (1984). Traumi sperimentali del midollo spinale: ruolo della Na,K ATPasi nella genesi dell’edema. Giornale di Medicina Militare 3: 199-203.

29 – Garay RP, Diez J, Nazaret C, Verna R, Dagher G, Hannaert P, Braquet P (1984). Are icosanoids involved in the regulation of ion transport? A possible role in essential hypertension. Prostaglandins vol. 27, 23.

30 – Cugini P, Verna R, Muraro R, Murano G, Scavo D (1984). 24-H patterns of erythrocyte membrane-bound Na/K ATPase and plasma aldosterone in obesity: a possible interpretative key to aldosteronism in hyperponderals. Eur. Rev. Med. & Pharm. Sci. VI, 181-188.

31 – Verna R., Braquet P., Diez J. and Garay R (1984). Effect of prostaglandins on the rat liver plasma membrane- bound Na/K ATPase. Prostaglandins 27, 72.

32 – Braquet P, Diez J, DeFeudis FV, Verna R and Garay R (1984). Regulation of Na and K transport in macrophages. Peptide hormones, biomembranes and cell growth; L.Bolis et al Eds. Plenum Press, New York, 63-78.

33 – Diez J, Braquet P, Verna R and Garay RP (1984). Are icosanoids involved in ion transport regulation?: II) a study in mouse macrophages. Prostaglandins and membrane ion transport, P.Braquet et al. eds. Raven Press, New York, 147-156.

34 – Diez J., Braquet P., Nazaret C., Verna R., Garay R (1984). The effect of icosanoids and cyclic nucleotides on Na and K transport in human red cells (HRC) and mouse elicited peritoneal macrophages (MM). Prostaglandins vol. 27, 26.

35 – Verna R, Braquet P, Cugini P and Garay R (1984). Chronobiology of Na/K ATPase activity in human erythrocyte membranes. Peptide hormones, biomembranes and cell growth. L. Bolis et al eds. Plenum Press, New York, pp. 79-88.

36 – Verna R (1984). Effect of prostaglandins on the rat liver plasma membrane bound Na/K ATPase. II. Prostaglandins and membrane ion transport, Braquet P et al. eds. Raven Press, New York 1984 pp. 227-233.

37 – Frati L, Cortesi E, Ficorella C, Manzari V and Verna R (1984). Phenotypic and genetic markers of cancer. Turning point in research. Genetic and phenotypic markers of tumors; S.A.Aaronson et al eds. Plenum Press, New York, pp.1-20.

38 – Verna R, Braquet P, Diez J and Garay R (1984). Evaluation of target cell responsiveness to peptide hormones: a possible role for the Na/K ATPase. Peptide hormones, biomembranes and cell growth; L.Bolis et al. Eds. Plenum Press, New York, pp. 51-62.

39 – Garay R, Diez J, Verna R, Nazaret C and Braquet P (1984). The involvement of cAMP in the hormonal regulation of ion transport. Peptide hormones, biomembranes and cell growth; L.Bolis et al. Eds. Plenum Press, New York, pp. 89-96.

40 – Diez J, Braquet P, Verna R, Nazaret C and Garay RP (1985). The effect of cAMP on Na and K transport systems in mouse macrophages. Experientia, 41, 5: 666-667.

41 – Baldini P, Incerpi S, Luly P and Verna R (1985). Insulin responsiveness of human erythrocyte plasma membrane. J. Physiol. (London), 127.

42 – Baldini P, D’Onofrio M, Incerpi S, Luly P, Rinaldi C, Verna R (1985). Insulin sensitivity of human red blood cells cation transport. Regulatory Peptides, 4, 26-29.

43 – Cugini P, Lucia P, Murano G, Letizia C, Pascale E, Verna R (1985). 24-h patterns of erythrocyte membrane-bound Na,K ATPase, plasma renin and aldosterone in normotensives and essential hypertensives. Regulatory peptides, 4, 148-151.

44 – Verna R, D’Amore L, D’Onofrio M, Galli C, Pascale E, Pozzi D and Frati L (1985). Protein phosphorylations, ion transport and the control of cell proliferation. Biomembranes in cancer cells, Galeotti et al eds. 1985 Elsevier N. Holland pp. 175-182.

45 – Singh TJ, Hochman J, Verna R, Chapman M, Abraham I, Pastan IH and Gottesman MM (1985). Characterization of a Cyclic AMP-resistant Chinese Hamster Ovary Cell Mutant Containing Both Wild-type and Mutant Species of Type I Regulatory Subunit of Cyclic AMP-dependent Protein Kinase. J. Biol. Chem. vol. 260, n.26, 13927-13933.

46 – Cugini P, Lucia P, Murano G, Letizia C, Scavo D, Verna R (1986). On determinants of circadian variability for blood pressure. Blood pressure recording in the clinical management of hypertension, G. Germanò (ed.), Edizioni Luigi Pozzi, Rome. pp. 55-68.

47 – Baldini P, Incerpi S, Pascale E, Rinaldi C, Verna R, Luly P (1986). Insulin effects on human red blood cells. Mol. and Cell. Endocrinology, 46, 93-102.

48 – Verna R, Galli C, Pascale E, Pozzi D, D’Amore L, Scarpa S, Frati L, Modesti A (1986). Prostaglandin-induced storage and secretion of estero- proteases in the mouse submaxillary gland. Cytobios, 46, 37-41.

49 – Cugini P, Letizia C, Lucia P, Scavo D, Verna R, Alessandri N, Accogli S, Passantino D, Scibilia G (1986). Ipertensione residua dopo correzione chirurgica della coartazione istmica dell’aorta: studio delle correlazioni tra alcuni fattori umorali e parametri emodinamici. Clinica e Terapia Cardiovascolare 3: 133, 159-163.

50 – Cugini P, Letizia C, Murano G, Lucia P, Scavo D and Verna R (1987). Internal desynchronization between circadian rhythms of plasma aldosterone and erythrocyte membrane-bound Na,K ATPase. Advances in chronobiology, 219-228, Alan Liss.

51 – Cugini P, Natali G, Gerlini G, Verna R, Di Palma L (1987). Deficiency in erythrocyte membrane-bound Na,K ATPase activity: a signal for aldosterone resistance syndrome (pseudohypoaldosteronism). The Journal of Pediatric Endocrinology, 2, 63.

52 – Grimaldi S, Pozzi D, Pascale E, D’Onofrio M, G.Giganti, Verna R, Monaco F and Roche J (1987). Recherches sur les proprietés fluorescentes de la Na,K ATPase. Compte Rendus. Societé de Biologie et Medicine. 6, 609-615.

53 – Grimaldi S, Pozzi D, Pascale E, D’Onofrio M, Giganti MG and Verna R (1988). Effect of ouabain binding on the fluorescent properties of the Na,K ATPase. Bioch. Bioph. Acta 944 : 13-18.

54 – Giacomelli R, Filingieri V, Famularo G, Calogero A, Stortoni F, Nardi S, Rosati R, Iacona A, Sacchetti S, Cervelli V, Verna R, Tonietti G and Casciani CU (1988). Cyclosporin A-H2 receptor antagonists drug interaction in the sprague-dawley rat. In: Current Therapy in  Nephrology, Martinus Nijoff, Boston 529-531.

55 – Grimaldi S, Pozzi D, Verna R, Lio S, Giganti MG, De Pirro R and Monaco F (1988). Enzymatic deglycosylation of human thyroglobulin: fluorescence studies. Bioch. Bioph. Acta 957: 105-110.

56 – Grimaldi S, Verna R, Puri A, Morris SJ and Blumenthal R (1988). Fusion of vesicular stomatitis virus with human red blood cell membranes: the role of phospholipid distribution. Advances in biotechnology of membrane ion transport. Serono Symposia Publications vol.51, 197-211, Raven Press.

57 – Grimaldi  S., Pozzi D, Verna R, Lio S, Napolitano G, Giganti G and Monaco F (1988). Fluorescence, hydrodynamic and immunological studies on human deglycosylated thyroglobulin (dTg). The Thyroid 1988. Nagataky S, Torizuka K eds, Elsevier Science Publishers B.V. pp 641-644.

58 – Cugini P, Lucia P, Letizia C, Murano G, Scavo D, Calogero A, Giganti MG, Verna R (1989). Chronobiologic evidence for an uncoupling of Na,K ATPase to aldosterone in normal renin hypertension: an escape of the ATPase-dependent Na,K pump from its major stimulator.

Enzyme, 41: 159-167.

59 – Grimaldi S, Lio S, Napolitano G, Satta MA, Pozzi D, Verna R and Monaco F (1989). Thyroid hormonogenesis: thyroglobulin and iodide metabolism. Experimental Clinical Endocrinology, 8; 83-88.

60 – Verna R, Giganti MG, Rota R, D’Onofrio M, Zanninelli G, Pascale E, Pozzi D and Grimaldi S (1989). Ion Transport and Cell Proliferation. In: Pathology of Gene Expression. Raven Press, 229-238.

61 – Pascale E, Aquino A and Verna R (1989). Retroviral Vectors: New Strategy in Gene Therapy.

Bioengineered Molecules, Basic and Clinical Aspects. Raven Press 1: 145-156.

62 -Frighi V and Verna R (1989). The Na+/H+ Antiport and its Role in Cell Regulation. Bioengineered Molecules, Basic and Clinical Aspects. Raven Press 1: 97-107.

63 – Verna R (1989). La membrana plasmatica come mezzo diagnostico. Aggiornamenti in Medicina di Laboratorio, Menarini 1: 51-60.

64 – Pascale E, D’Onofrio M, Aquino A, Verna R (1989). Il DNA Ricombinante nella Diagnostica clinica. Aggiornamenti in Medicina di Laboratorio. Menarini 1: 169- 178.

65 – Verna R (1989). Membrane technology applied to laboratory diagnosis. Membrane Technology, Raven Press, vol.64 pp.143-153.

66 – D’Onofrio M, Verna R (1991). La reazione Polimerasica a Catena (PCR): metodologie di base ed applicazioni diagnostiche. Atti del XLI Congresso Nazionale AIPaC, 157- 168.

67 – Caramia FG, Ceccarelli G, Mastrantoni M, Evangelista M, Masuelli L, Giganti MG, Modesti A and Verna R (1990). Effect of hypocholesterolemizing treatment with A585 on plasma membrane functionality and liver electron microscope appearance in rats. Current Therapeutic Research, 48, 5: 790-797.

68 – Borgia MC, Borgia C, Betto P, Partemi I, Giganti MG, Verna R (1991). Early detection of the catecholamine-induced sodium, potassium pump-dependent genesis of arrhythmias in acute  myocardial infarction. Current Therapeutic Research, 49, 5, 823-831.

69 – Verna R, D’Onofrio M, Pascale E (1991). Le biotecnologie nella diagnostica di laboratorio. Il Patologo Clinico, 1, 6-14, (Editoriale).

70 – Giganti MG, Pignatelli E, Modesti D, Masella R, Cantafora A and Verna R (1991). On the Mechanisms of Aging. Age-Related Changes of Transmembrane Na and K Fluxes: Their Relationship with Membrane and Circulating Lipids. Biotechnology of Cell Regulation, Serono Symposia Series “Advances in Experimental Medicine” vol.4, 457-470.

71 – Verna R, Giganti MG, Modesti D, Pignatelli E, Vecchio I, Masella R and Cantafora A (1992). Prospettive diagnostiche della ricerca sui markers dell’invecchiamento. Il Patologo Clinico n.10: 1-8.

72 – Nardi P, Chiappetta F, Giancola R, Sinibaldi P and Verna R (1992). Involvement of the membrane-bound Na.K ATPase in the evolution of experimental injuries of the spinal cord. J Neuros Sci 36: 4, 197-200.

73 – Cantafora A, Masella R, Pignatelli E and Verna R (1992). Influence of age on the lipoprotein profile of male Wistar rats. Archives Gerontology and Geriatrics, 3, 93-100.

74 – Cugini P, Natoli G, Gerlini G, Di Palma L, Rota R, D’Onofrio M and Verna R (1992). Erythrocyte Transmembrane Na and K Fluxes in Pseudohypoaldosteronism. Biochemical Medicine and Metabolic Biology, 48: 3, 241-254.

75 – Pascale E, Verna R (1992). Applicazioni delle tecniche di analisi del DNA alle scienze forensi. Il Patologo Clinico 9, 690-695.

76 – Verna R (1992). L’Acido folico ed i suoi derivati: biochimica metabolica, fisiopatologia e metodi analitici. L’acido folico: basi fisiopatologiche per la terapia degli stati carenziali, Cairella M e Verna R eds, Il Pensiero Scientifico Editore, pp.3-17.

77 – Cantafora A, Masella R, Pignatelli E and Verna R (1993). Age- related changes in blood and liver lipids of male wistar rats. Arch Gerontol Geriatr 16, 249-262.

78 – Giganti MG, D’Onofrio M, Modesti D, Cantafora A and Verna R (1993). Effect of different diets on markers of aging. General Pathology and Pathophysiology of Aging, Bergamini E ed, Wichtig Milano, 129-135.

79 – Verna R (1993). Fisiopatologia del controllo endocrino del ricambio idro-salino. Invited Lecture, atti V° congresso internazionale della European Communities Biologists Association, vol II; 345-63.

80 – Bravo E, Pignatelli E, Masella R, Verna R and Cantafora A (1994). Influence of age on hepatic uptake of HDL1- cholesterol in male Wistar rats with bile duct cannulation. J Biochem, 115, pp. 833-836 1994.

81 – D’Onofrio M, Verna R (1993). Marcatori genomici nella diagnostica di laboratorio dei tumori della mammella. In: Il ruolo della biologia nella diagnostica del 2000; atti VI° congresso internazionale della European Communities Biologists Association, pp. 73-82.

82 – Verna R and D’Onofrio M (1994). Application of Recombinant DNA Technology to the Laboratory Diagnostics of Cardiovascular Diseases. I: Atherosclerosis. Eur J Lab Med, vol. 2, n. 1 pp.57-61.

83 – Verna R (1994). Biotechnology for the Molecular Characterization of Atherosclerosis and Hypertension. Biotechnology Today, Serono Symposia Series “Challenges in Medicine” vol 5, 1-10.

84 – Pignatelli E, Masella R, Marinelli T, Modesti D, Verna R and Cantafora A (1994). Effect of dietary fats on plasma and liver lipids of young and adult male Wistar rats. Eur J Lab Med, vol. 2, n. 3 pp.191-196.

85 – Aslanian NL, Mkrtchian WA, Adamian KG, Hovhannissian HT, Verna R, Cugini P (1995). Cardiogenic Cytokines: method of production and their action on heart functions. Eur J Lab Med, 3; 1: 27-30.

86 – Verna R, Giganti MG, Modesti D, Giancola R, Pignatelli E, Masella R, Cantafora A (1994). Lipidi ed invecchiamento. Alim. Nutriz. e Met., vol. 15, n. 1, pp. 3-14.

87 – Masella R, Pignatelli E, Marinelli T, Modesti D, Verna R and Cantafora A (1995). Age-related variations in plasma and liver lipids of Yoshida rats. Comparison with Wistar rats. Comp. Biochem. and Physiology, 111 B, 2: 319-327.

88 – Bruni L, Angeletti B, Pascale E, Tozzi M.C, Giammaria P, Verna R and D’Ambrosio E (1996). Exclusion of Treacher-Collins Franceschetti syndrome in a subject with tetralogy of Fallot and cryptorchidism. Clinical Genetics, 50 : 2, 89-92.

89 – Angeletti B, Pascale E, Verna R, Passarelli F, Butler RH, D’Ambrosio E (1996). Differential expression of heat shock protein (HSP70) mRNAs in rat cells. Expl Cell Res, 227, 160-164.

90 – Battiloro E, Angeletti B, Tozzi MC, Bruni L, Tondini S, Vignetti P,  Verna R, D’Ambrosio E (1997). A novel double nucleotide substitution in the HMG box of the SRY gene associated to Swyer syndrome. Human Genetics 100, 585-587.

91 – Zanninelli G, Choundry R, Loréal O, Guyader D, Lescoat G, Arnaud J, Verna R, Cosson B, Singh S, Hider CR and Brissot P (1997). Novel orally active iron chelators (3-hydroxypyridin-4-ones) enhance the biliary excretion of plasma non-transferrin-bound iron in rats. J Hepatol 27: 176-184.

92 – Masella R, Pignatelli E, Modesti D, Marinelli T, Giancola R, Verna R, Cantafora A (1996). Effect of dietary lipids on age-related lipemic variations in spontaneously dyslipidemic Yoshida rats. Eur J Lab Med, 4, 3: 198-205.

93 – Sisakian HS, Verna R, Aslanian NL, Mkrtchian WA (1996). Relationship between plasma norepinephrine levels and echocardiographic variables in patients with dilated cardiomiopathy. Eur J Lab Med, 4: 3, 210-212.

94 – Verna R (1996). Valutazione delle metodiche di laboratorio per la rilevazione dell’epatite infettiva da virus C (HCV). Il Patologo Clinico, 5: 294-300.

95 – Falchetti ML, Levi A, Molinari P, Verna R, D’Ambrosio E (1998). Increased sensitivity and reproducibility of TRAP assay by avoiding direct primers interaction. Nucl Ac Res 26, 3: 862-863.

96 – Arca M, Verna R (1998). Diagnostica molecolare delle iperlipoproteinemie e degli altri fattori di rischio dell’arteriosclerosi. In: La diagnostica di laboratorio con i metodi della biologia molecolare, Piccin – Padova, pp176-214.

97 – Verna R, D’Ambrosio E (1998). Il DNA ripetitivo: un nuovo strumento per la diagnostica molecolare. In: La diagnostica di laboratorio con i metodi della biologia molecolare, Piccin – Padova, pp125-141.

98- M.Arca, F.Campagna, A.Montali, L.Flora, A.Gaddi, C.Galletti, G.Casari, M.Devoto, E.D’Ambrosio, R.Verna: Genome-wide search for linkage mapping of susceptibility genes for familial combined hyperlipidemia (FCHL). Atherosclerosis 138 (Suppl. 1); S8, 1998

99 – Falchetti ML, Falcone G, D’Ambrosio E, Verna R, Alemà S, Levi A. Induction of telomerase activity in v-myc transformed avian cells. Oncogene, 1999; 18, 1515-1519.

100 – Falchetti ML, Pallini R, Larocca LM, Verna R, D’Ambrosio E (1999). Telomerase expression in intracranial tumors: prognostic potential for malignant gliomas and meningiomas. J Clin Pathol, 52,3,234-236.

101 – Falchetti ML, D’Ambrosio E, Verna R (1998). I telomeri e la telomerasi. Il Patologo Clinico, 5-6, 137-141.

102 – Verna R, Cimino Reale G, Nosseri C, Varrassi, S, Verna F, D’Ambrosio E. (1999). Microsatellites in molecular diagnosis of disease. In: Woman’s health in 2000. EV Cosmi ed.

103 – Battiloro E, Andreoni M, Parisi SG, Mura MS, Sotgiu G, Aceti A, Cossu G, Concia E, Verna R, D’Ambrosio E (2000). Distribution of the CCR-5 D32 allele in Italian HIV type 1-infected and normal individuals. AIDS Research and Human Retroviruses 16, 2 january 20, 181-182.

104 – Battiloro E, Ombres D, Pascale E, D’Ambrosio E, Verna R, Arca M (2000). Haemochromatosis gene mutations and risk of coronary artery disease. Eur J Human Genetics, 8, 389-392.

105 – Pascale E, Tarani L, Meglio P, Businco L, Battiloro E, Cimino Reale G, Verna R and D’Ambrosio E (2001). Absence of association between a variant of the mast cell chymase gene and atopic dermatitis in an italian population. Human Heredity, 51: 177-179.

106 – Falchetti ML, Pallini R, D’Ambrosio E, Pierconti F, Martini M, Cimino Reale G, Verna R, Larocca LM (2000). In situ detection of telomerase catalytic subunit mRNA in glioblastoma multiforme. Int J of Cancer Dec 15;88(6):895-901.

107 – Verna R, Cama G, Arca M, Corsi MM, D’Onofrio G (2000). Il Laboratorio di Patologia Clinica nell’attività sportiva. Prima parte Cenésthesis 4, 10-19.

108 – Verna R, Cama G, Arca M, Corsi MM, D’Onofrio G (2000). Il Laboratorio di Patologia Clinica nell’attività sportiva. Seconda parte. Cenésthesis 5, 36-39.

109 – Cimino Reale G, Pascale E, Battiloro E, Starace G, Verna R, D’Ambrosio E (2001). The length of telomeric G-rich strand 3′-overhang measured by oligonucleotide ligation assay. Nucleic Acid Research, Apr 1;29(7):E35

110 – Arca M, Montali A, Ombres D, Battiloro E, Campagna F, Ricci G, Verna R (2001). Lack of association of the common TaqIB polymorphism in the cholesteryl ester transfer protein gene with angiographically assessed coronary atherosclerosis. Clin Gen, 60, 374-380.

111 – Arca M, Ombres D, Montali A, Campagna F, Enrico M, Gaetano T, Campa PP, Ricci G, Verna R and Pannitteri G (2002). PON1 L55M polymorphism is not a predictor of coronary atherosclerosis either alone or in combination with Q192R polymorphism in an italian population. Eur J Clin Invest;32(1):9-15.

112 – Arca M, Campagna F, Baroni MG, Montali A, Ricci G and Verna R (2002). The common variants in the lipoprotein lipase (LPL) gene, but not those in the insulin receptor substrate-1 (IRS-1), the B3 adrenergic receptor (b3-AR) and the intestinal fatty acid binding protein-2 (FABP-2) genes influence lipid phenotypic expression in familial combined hyperlipidemia. Metabolism, 2002 Oct;51(10):1298-305.

113 – Verna R, Ravazzolo M (2002). La tutela della salute nelle attività sportive e la lotta al doping: nuove opportunità per il patologo clinico. Il Patologo Clinico 9-12; 384-394.

114 – Verna R, Ravazzolo M (2003). Nuove strategie per la tutela della salute nelle attività sportive e per la lotta al doping. Quaderni Fondazione Piaggio, II, 130-160.

115 – Verna F, Di Giuli M, Venditti A, Corsi M. M, Verna R (2003). Radicali liberi e specie reattive dell’ossigeno in patologia umana ed in diagnostica di laboratorio. Il Patologo Clinico, 3-4; 62-72.

116 –  Banfi G, Dolci A, Verna R, Corsi M. M. (2004). Exercise raises serum heat-shock protein 70 (Hsp70) levels. Clin Chem Lab Med 42(12):1445-6.

117 – Brando B, Longo A, Beltrami B, Passoni D, Verna R, Licastro F, Corsi M.M. (2004). Determination of telomere length by flow fluorescence in situ hybridization in Down’s syndrome patients. Int J Tissue React.; 26(1-2):61-4.

118 – Cavallo M.G., Montali A, Monetini L, Valente L, Mariani P, Bifolco M, Sirinian MI, Antonini TM, Fioretti F, Campagna F, Verna R, Arca M (2005).  Tumor necrosis factor alpha (TNFalpha) and its soluble receptor p75 (sTNF-R p75) in familial combined hyperlipidemia (FCHL). Nutr Metab Cardiovasc Dis. Aug;15(4):262-9. (1,679)

119 – Sirinian MI, Belleudi F, Campagna F, Ceridono M, Garofalo T, Quagliarini F, Verna R, Calandra S, Bertolini S, Sorice M, Torrisi MR, Arca M (2005). Adaptor protein ARH is recruited to the plasma membrane by LDL binding and modulates endocytosis f the LDL/LDLR complex in hepatocytes. J Biol Chem, Aug 2005; doi:10.1074/jbc.M504343200   IF 5,854

120 – Banfi G, Dolci A, Malavazos A, Doneda L, Verna R and Corsi MM (2006). Serum oxidant and antioxidant status and presence of  nitric oxide and heat shock protein 70 in trained elite soccer players. Eur J Appl Physiol Mar;96(5):483-6. Epub 2005 Dec 13.

121 – Banfi G, Malavazos A, Iorio EL, Dolci A, Doneda L, Verna R, Corsi MM (2006). The iron-o-dianisidine/xylenol orange assay in comparative oxidative stress assessment. Some possible shortcomings. Eur J Appl Physiol. Jul; 97(4):506-8. Epub May 18.

122 –  Corsi M.M , Pagani D, Iorio EL, Dogliotti G, Verna R, Sambataro G, Pignataro L (2006). Blood reactive oxygen metabolites (ROMs) and total antioxidant status (TAS) in patients with laryngeal squamous cell carcinoma after surgical treatment. Clin Chem Lab Med;44(8):1047-8.

123 – Crivello A, Giacalone A, Vaglica M, Scola L, Forte GI, Macaluso MC, Raimondi C, Di Noto L, Bongiovanni A, Accardo A, Candore G, Palmeri L, Verna R, Caruso C, Lio D, Palmeri S (2006). Regulatory cytokine gene polymorphism and risk of colorectal cancer. Ann NY Acad Sci 1-6

124 – Scola L, Vaglica M, Crivello A, Palmeri L, Forte GI, Macaluso MC, Giacalone A, Di Noto L, Bongiovanni A, Raimondi C, Accardo A, Verna R, Candore G, Caruso C, Lio D, Palmeri S (2006). Cytokine gene polymorphisms and breast cancer susceptibility. Ann N Y Acad Sci, 9 – 12

125 –  Campagna F, Martino F, Bifolco M, Montali A, Martino E, Morrone F, Antonini R, Cantafora A, Verna R, Arca M (2006). Detection of familial hypercholesterolemia in a cohort of children with hypercholesterolemia: Results of a family and DNA-based screening. Atherosclerosis. Dec 27; 196(1):356-64. [Epub ahead of print].  IF 3,77

126 – Forte GI, Piccione M, Scola L, Crivello A, Galfano C, Corsi MM, Chiappelli M, Candore G, Giuffre M, Verna R, Licastro F, Corsello G, Caruso C, Lio D. Apolipoprotein E Genotypic Frequencies among Down Syndrome Patients Imply Early Unsuccessful Aging for ApoE4 Carriers. Rejuvenation Res. 2007 Sep;10(3):293-9 Jun 9[Epub ahead of print].  IF 8,353

127 – Arca M, Conti B, Montali A, Pignatelli P, Campagna F, Barillà F, Tanzilli G, Verna R, Vestri A, Gaudio C, Violi F. C242T polymorphism of NADPH oxidase p22phox and recurrence of cardiovascular events in coronary artery disease. Arterioscler Thromb Vasc Biol. 2008 Apr;28(4):752-7. Epub 2008 Jan 31

128 – Filigheddu F, Quagliarini F, Campagna F, Secci T, Degortes S, Zaninello R, Argiolas G, Verna R, Pitzoi S, Frau F, Troffa C, Bulla E, Bertolini S, Glorioso N, Arca M. Prevalence and clinical features of heterozygous carriers of autosomal recessive hypercholesterolemia in Sardinia. Atherosclerosis 2009;207(1):162-7

129 – TESPI (Thrombolysis in Elderly Stroke Patients in Italy): a randomized controlled trial of alteplase (rt-PA) versus standard treatment in acute ischaemic stroke in patients aged more than 80 years where thrombolysis is initiated within three hours after stroke onset.

Lorenzano S, Toni D; TESPI trial Investigators. Int J Stroke. 2012 Apr;7(3):250-7. doi: 10.1111/j.1747-4949.2011.00747.x. Epub 2012 Jan 31.

130 – A useful relationship between the presence of extramedullary erythropoeisis and the level of the soluble form of the transferrin receptor in a large cohort of adult patients with thalassemia intermedia: a prospective study. Ricchi P, Ammirabile M, Costantini S, Di Matola T, Verna R, Diano A, Foglia MC, Spasiano A, Cinque P, Prossomariti L. Ann Hematol. 2012 Jun;91(6):905-9. Epub 2011 Dec 15.

131 – The history and science of chocolate. Verna R. Malays J Pathol. 2013 Dec;35(2):111-21

132 – Biosensor-Based Multisensorial System: Technological Design and Clinical Applications.          Verna R, D’Amico A, Santonico M, Pennazza G, Verna F, Bizzarri M. The American Journal of  Pathology, Vol. 184, September 2014; S1

133 – Quantitative Morphological Discrimination of Chemo-resistant and Wild-type Cancer Cells.

          Verna R, Palombo A, Pasqualato A, D’Amico A, Verna F, Bizzarri M, Cucina A. The American Journal of  Pathology, Vol. 184, September 2014, S4

134 – Multi-sensor Acquisition of Pathophysiological Markers in Sport Activities Monitoring

          Verna R, D’Amico A, Bizzarri M, Verna F, Palombo A. The American Journal of  Pathology, Vol. 184, September 2014, S20

135 – Gender Medicine: A Novel Interpretation of Equal Opportunities? Verna R, Verna F, Bizzarri M. The American Journal of  Pathology, Vol. 184, September 2014; S37

136 – Soluble form of transferrin receptor as a biomarker of overall morbidity in patients with non-  transfusion-dependent thalassaemia: a cross-sectional study.

Ricchi P, Ammirabile M, Costantini S, Spasiano A, Di Matola T, Verna R, Pepe A, Cinque P, Saporito C, Filosa A, Pagano L. Blood Transfus. 2016 May 3:1-3. doi: 10.2450/2016.0279-15.

137 – Si può fare prevenzione risparmiando? R. Verna, Quotidiano Sanità, 20 maggio 2016

138 – Is it possible to change lifestyle habits, prevent disease and reduce health spending? Verna R.

The American Journal of Pathology, 2016  vol 186, 30.

INVITED LECTURES

1 – Tria E, Luly P, Verna R (1974). Attivazione da aminoacidi della (Na/K) ATPasi di membrane plasmatiche isolate da fegato di ratto. Congresso S.I.B.S. abs. 94.

2 – Leoni S, Spagnuolo S, Luly P, Mangiantini MT, Trentalance A and Verna R (1974). Attività Adenilciclasica e ATPasica nel fegato di ratto durante la rigenerazione. Congresso S.I.B.S. abs. n. 199.

3 – Frati L, D’Armiento M, Faggioni A, Torrisi MR and Verna R (1978). Epidermal Growth Factor (EGF) cAMP and entrance of the hormone into sensitive cells. Int. Symposium – Cyclic Nucleotides, Paris.

4 – Caramia FG, D’Armiento M, Lauro R, Verna R (1978). Phosphodiesterase activity in genetically hypertensive rats aorta. Int. Symposium – Cyclic nucleotides, Paris.

5 – Frati L, Lacerna F, Faggioni A, Torrisi MR, Verna R (1978).

Improved in vitro test for assessing the sensitivity of human tumors to antiblastic drugs. I Mediterranean congress of chemotherapy, Madrid.

6 – Verna R, Muraro R, Dondoli J, Caramia FG (1981). Attivita’ Na/K ATPasica nell’ipertensione. In: L’immunità nella patogenesi delle malattie, Atti del XVI Congresso Naz. della Soc. Italiana di Patologia, 463-464

7 – Verna R, Cugini P, Dondoli J, Muraro R (1981). Attività ritmica della Na/K ATPasi. In: L’immunità nella patogenesi delle malattie, Atti del XVI Congresso  di Patologia, 465-466

8 – Verna R, Gottesman MM and Frati L (1982). Na/K ATPase and cell growth. V: a marker of neoplastic growth? International workshop on membranes and tumor growth, Roma, 157-158

9 – Verna R, D’Onofrio M, R. Pesce, Pozzi D, Diez J, Braquet P and Garay R (1984). Ruolo del cAMP nella regolazione dei flussi cationici. XVII Congresso Naz. della Società Italiana di Patologia, Firenze pag. 121

10 – Verna R, Pozzi D, D’Onofrio M, Pesce R, Braquet P and Garay R (1984). Cronobiologia delle plasma membrane: variazioni cicliche della Na/K ATPasi. XVII Congresso Naz. della Società Italiana di Patologia, Firenze pag. 122

11 – Diez J, Braquet P, Verna R, Garay R (1984). Regulation of ion transport by prostaglandins in mouse macrophages. 5th Future Trends in Inflammation, Venice, April 16-18.

12 – Bellussi L, Masieri S, Sciuto A, Calogero A, Berlizzi E, Verna R and Passali D (1988). Immunohystochemical study of cholesteatomas. Copenhagen Cholesteatome Conference.

13 – Nardi P, Bruni P, Esposito S, Rota R, Calogero A, Verna R (1988). Attività Na,K ATPasica nel coiling della carotide umana. XXVIII Congresso Nazionale della S.N.O.

14 – Filingieri R, Giacomelli R, Famularo G, Rosati R, Calogero A, Nardi S, Iacona A, Stortoni F, Sacchetti S, Cervelli V, Verna R, Tonietti G and Casciani CU (1988). Experimental hepatotoxicity induced by cyclosporin (CyA). International symposium on Cyclosporin in autoimmune diseases and organ transplantation, Brescia.

15 – Pozzi D, Grimaldi S, Napolitano G, Lio S, Verna R, Monaco F (1988) Enzymatic deglycosylation of human thyroglobulin: fluorescence studies. J Endocrinol Invest 11 (suppl 2), 55.

16 – Grimaldi S, Pozzi D, Rota R, Jacovacci S, Mussolini A, Verna R (1988). Studio della correlazione fra struttura e funzione della Na,K ATPasi mediante spettroscopia in fluorescenza. 34° Congresso della Società Italiana di Biochimica, abs C IX 27.

17 – Cugini P, Letizia C, Murano G, Lucia P, Scavo D, Verna R (1986).

Internal desynchronization between circadian rhythms of plasma aldosterone and erythrocyte membrane-bound Na,K ATPase.

Chronobiologia pag. 166.

18 – D’Onofrio M, Pascale E, Hanover J, Verna R (1990). Caratterizzazione molecolare del complesso del poro nucleare. Soc. It. Patol., XX Congresso Nazionale, Modena.

19 – Giganti MG, Evangelista M, Fonti R, Pignatelli E, Caramia FG, Verna R (1990). Effetti del trattamento ipocolesterolemizzante sulla funzionalità della membrana plasmatica. SIP, XX Congresso Nazionale, Modena.

20 – Rota R, Cugini P, Natoli G, Gerlini G, Di Palma R, Verna R (1990). Activité des systemes erythrocytaires de transport du Na et du K dans le PHA.

Archives des maladies du coeur et des vaisseaux. 83, 56.

21 – Giganti MG, Modesti D, Pignatelli E, Verna R (1992). Marcatori biochimici e cellulari dell’invecchiamento. Atti del XXI Congresso Nazionale della Società Italiana di Patologia, 237-239.

22 – D’Onofrio M, Colletta G, Hanover JA, Verna R (1992). Il gene che codifica la glicoproteina del poro nucleare di ratto, P62, è un gene privo di introni. Atti del XXI Congresso Nazionale della Società Italiana di Patologia, 321-323.

23 – Rota R, Dausse E, Guicheney P, Verna R (1992). Mancanza di correlazione tra l’iperproliferazione di fibroblasti cutanei di ratti geneticamente ipertesi (SWHR) e l’ipertensione arteriosa: analisi di una generazione di ratti ibridi F2 (SHRxWKY). Atti del XXI Congresso Nazionale della Società Italiana di Patologia, 330-332.

24 – Zanninelli G, Gollan JL, Guyader D, Brissot P, Verna R (1992). Difetto significativo di escrezione biliare del ferro non legato alla transferrina nella emocromatosi sperimentale indotta nel ratto. Atti del XXI Congresso Nazionale della Società Italiana di Patologia, 543-545.

25 – Pascale E, Furano AV, Verna R (1992). Amplificazione episodica di elementi L1 di DNA ripetuto. Atti del XXI Congresso Nazionale della Società Italiana di Patologia, 546- 548.

26 – Masella R, Pignatelli E, Marinelli T, Giganti MG, Verna R and Cantafora A (1993). Age-related changes in liver lipid composition of Yoshida rats. A comparison with Wistar rats. 5° congress of the international association of biomedical gerontology (IABG), Budapest, July 1-3, 1993.

27 – Cantafora A, Masella R, Pignatelli E, Modesti D and Verna R (1993). Age-related cholesterol alterations in male Wistar rats: effect of dietary fats on plasma and liver lipids. 5° congress of the international association of biomedical gerontology (IABG), Budapest, July 1-3, 1993.

28 – Battiloro E, Bruni L, Vignetti P, Angeletti B, Verna R, D’Ambrosio E. Mutational analysis in 46,XY sex reversal. ATB, 1995.

29 – Pascale E, Angeletti B, D’Ambrosio E and Verna R (1995). Diagnosis of fragile-X syndrome by ethidium-stained PCR. ATB, 1995

30 – Falchetti ML, Caronti B, D’Ambrosio E, Palladini G, Verna R (1997). Evaluation of telomerase activity in central nervous system neoplasias by telomeric repeat amplification protocol (TRAP). Congress of Molecular Medicine, Berlin, 3-6 June 1997.

31 – Angeletti B, Battiloro E, Tozzi MC, Bruni L, Verna R, D’Ambrosio E (1997). A novel double nucleotide substitution in the HMG box of the SRY gene associated to Swyer syndrome. Congress of Molecular Medicine, Berlin, 3-6 June 1997.

32 – Falchetti ML, Caronti B, Palladini G, D’Ambrosio E, Verna R (1997). Studio dell’attività telomerasica di tumori del sistema nervoso centrale mediante TRAP (Telomeric Repeat Amplification Protocol). XLVIII Congresso Nazionale AIPaC.

33 – Battiloro E, Molinari P, D’Ambrosio E, Verna R (1997). Prevalenza della mutazione “del32” del gene CCR5 in una popolazione del centro Italia. XLVIII Congresso Nazionale AIPaC.

34 – Caracciolo C, Pascale E, D’Ambrosio E, Verna R (1997). Il ruolo delle mutazioni Cys282Tyr e His63Asp del gene HLA-H nell’emocromatosi. XLVIII Congresso Nazionale AIPaC.

Doping ieri, oggi, domani. Accademia di Medicina, Torino, 2012

35 – Patogenesi del danno endoteliale e renale. Urinology 2013, Abano Terme 6-7 maggio 2013.

Il cioccolato tra storia e scienza. 17° Convegno  Patologia Immune e Malattie Orfane

Torino, 30-31 gennaio 2014

36 – Sport e salute. Cagliari 11 settembre 2013

37 – Pathogenesis of Endothelial and Renal Damage. ICPaLM  Congress, Kuala Lumpur, august 2014

38 – Health and Gender.

Lo Sport come prevenzione e cura dell’obesità giovanile

39 – Dall’alchimia alla Medicina Personalizzata. Napoli giugno 2015

39 – Pathogenesis of Endothelial and Renal Damage. WASPaLM World Congress, Cancun (MX) Nov. 2015

40 – I Principi della Nutrizione nelle Attività Estreme. Expo 2015

BOOKS

Peptide hormones, biomembranes and cell growth.

L. Bolis, R. Verna and L. Frati Eds. Plenum Publishing Co. New York and London, 1984

Genetic and phenotypic markers of tumors.

S.A. Aaronson, L. Frati and R. Verna Eds. Plenum Publishing Co. New York and London, 1984

Peptides and ion transport

P.Braquet, R.Garay, G.Racagni, R.Paoletti and R.Verna eds.

Regulatory Peptides, Supplement 4, Elsevier North-Holland 1985.

Advances in Biotechnology of Membrane Ion Transport. P.L. Jorgensen and R. Verna Eds. Serono Symposia Publications vol.51, Raven, N.Y.

Aggiornamenti in Medicina di Laboratorio, Roberto Verna Ed. Menarini 1989.

Bioengineered Molecules: Basic and Clinical Aspects. R.Verna, R.Blumenthal and L.Frati Eds. Serono Symposia Series “Advances in Experimental Medicine” vol.1, Raven, N.Y. 1989.

Membrane Technology. R. Verna Ed. Serono Symposia Publications vol 64, Raven N.Y. 1989.

Biotechnology of Cell Regulation. R. Verna, Y. Nishizuka eds. Serono Symposia Series “Advances in Experimental Medicine” vol. 4 1991 Raven Press.

I Folati. Aspetti Fisiopatologici e Terapeutici.

M. Cairella, R. Verna

Il pensiero Scientifico, 1992.

Biotecnologia Clinica: Principi ed Applicazioni

R. Verna

Il Pensiero Scientifico, 1994.

Biotechnology Today

R. Verna and A.E. Shamoo.

Serono Symposia Series, 1994.

La diagnostica di laboratorio con i metodi della biologia molecolare

  1. Verna

Piccin Editore, 1998.

Medicina di Laboratorio

Michael Laposata

Edizione Italiana a cura di R. Verna

(Pub Med, Web of Knowledge e SCOPUS).

•    Impact Factor Totale:            187,078
•    Impact Factor Medio:              3,07
•    N. Citazioni Totali                716
•    N. Citazioni Medie (Normalizzato):       18.35
•    H Index:                  17
•    H Index Contemporaneo:             9

 

LABORATORY LAYOUT AND FACILITIES

The laboratory makes use of numerous equipment and instruments located in the main center in via Scarpa 16 (building RM039), also distributed in other structures within the University. The main ones of which are:

  1. Laboratory of simulated weightlessness. The lab owns a Random Positioning Machine through which selective gravity values – from the almost ~0g of the International Space Station to the 0.16 and 0.38 g of the Moon and Mars respectively – can be properly simulated and investigated.
  2. Laboratory of Analytical studies. This section includes HPLC/MS devices for advanced analytical studies.
  3. Laboratory of Molecular Biology. Within this section Western-blot and immunofluorescence analysis can be performed, altogether with investigations based upon PCR. The section can provide cell and organoids cultures, in both 2D and 3D.
  4. Laboratory of Confocal Microscopy. This section deals with morphological and ultra-structural studies carried out on cells, tissues and organoids.
  5. Animal facility. The animal facility support in vivo experiments for animal housing and management.