Bizzarri M. , P. Gaudenzi, A. Angeloni. The Biomedical challenge associated with the Artemis space program. Acta Astronautica, 212 (2023) 14–28.

Tsuchiya, M.; Brazhnik, P.; Bizzarri M.; Giuliani, A. Synchronization between Attractors: Genomic Mechanism of Cell-Fate Change. Int. J. Mol. Sci. 2023, 24, 11603.

Monti N, Dinicola S, Querqui A, Fabrizi G, Fedeli V, Gesualdi L, Catizone A, Unfer V, Bizzarri M. Myo-Inositol Reverses TGF-β1-Induced EMT in MCF-10A Non-Tumorigenic Breast Cells. Cancers (Basel). 2023 Apr 15;15(8):2317. doi: 10.3390/cancers15082317. PMID: 37190245; PMCID: PMC10136889.

Bizzarri M. , Monti N, Piombarolo A, Angeloni A, Verna R. Myo-Inositol and D-Chiro-Inositol as Modulators of Ovary Steroidogenesis: A Narrative Review. Nutrients. 2023 Apr 13;15(8):1875. doi: 10.3390/nu15081875. PMID: 37111094; PMCID: PMC10145676.

Fedeli V, Catizone A, Querqui A, Unfer V, Bizzarri M. The Role of Inositols in the Hyperandrogenic Phenotypes of PCOS: A Re-Reading of Larner’s Results. Int J Mol Sci. 2023 Mar 27;24(7):6296. doi: 10.3390/ijms24076296. PMID: 37047265; PMCID: PMC10093919.

Bizzarri M. , Fedeli V, Piombarolo A, Angeloni A. Space Biomedicine: A Unique Opportunity to Rethink the Relationships between Physics and Biology. Biomedicines. 2022 Oct 19;10(10):2633. doi: 10.3390/biomedicines10102633. PMID: 36289894.

Bizzarri M., Giuliani A. Soft Statistical Mechanics for Biology. Methods Mol Biol. 2022;2449:263-280. doi: 10.1007/978-1-0716-2095-3_11. PMID: 35507267.

Bizzarri M., Fedeli V, Monti N, Cucina A, Jalouli M, Alwasel SH, Harrath AH. Personalization of medical treatments in oncology: time for rethinking the disease concept to improve individual outcomes. EPMA J. 2021 Oct 7:1-14. doi: 10.1007/s13167-021-00254-1. Epub ahead of print. PMID: 34642594; PMCID: PMC8495186.

Verna R, Alallon W, Murakami M, Hayward CPM, Harrath AH, Alwasel SH, Sumita NM, Alatas O, Fedeli V, Sharma P, Fuso A, Capuano DM, Capalbo M, Angeloni A, Bizzarri M. Analytical Performance of COVID-19 Detection Methods (RT-PCR): Scientific and Societal Concerns. Life (Basel). 2021 Jul 6;11(7):660. doi: 10.3390/life11070660. PMID: 34357032; PMCID: PMC8305061.

Minini M, Senni A, He X, Proietti S, Liguoro D, Catizone A, Giuliani A, Mancini R, Fuso A, Cucina A, Cao Y, Bizzarri M. miR-125a-5p impairs the metastatic potential in breast cancer via IP6K1 targeting. Cancer Lett. 2021 Nov 1;520:48-56. doi: 10.1016/j.canlet.2021.07.001. Epub 2021 Jul 3. PMID: 34229060.

Bizzarri M., Pontecorvi P. Critical transition across the Waddington landscape as an interpretative model: Comment on “Dynamic and thermodynamic models of adaptation” by A.N. Gorban et al. Phys Life Rev. 2021 Jun 6:S1571-0645(21)00039-7. doi: 10.1016/j.plrev.2021.05.010. Epub ahead of print. PMID: 34116954.

Monastra G, Vucenik I, Harrath AH, Alwasel SH, Kamenov ZA, Laganà AS, Monti N, Fedeli V, Bizzarri M. PCOS and Inositols: Controversial Results and Necessary Clarifications. Basic Differences Between D-Chiro and Myo-Inositol. Front Endocrinol (Lausanne). 2021 Apr 6;12:660381. doi: 10.3389/fendo.2021.660381. PMID: 33889133; PMCID: PMC8056130.

Monti N, Masiello MG, Proietti S, Catizone A, Ricci G, Harrath AH, Alwasel SH, Cucina A, Bizzarri M. . Survival Pathways Are Differently Affected by Microgravity in Normal and Cancerous Breast Cells. Int J Mol Sci. 2021 Jan 16;22(2):862. doi: 10.3390/ijms22020862. PMID: 33467082; PMCID: PMC7829699.

Minini M, Senni A, Unfer V, Bizzarri M. The Key Role of IP6K: A Novel Target for Anticancer Treatments? Molecules. 2020 Sep 25;25(19):4401. doi: 10.3390/molecules25194401. PMID: 32992691; PMCID: PMC7583815.

Bizzarri M. , Di Traglia M, Giuliani A, Vestri A, Fedeli V, Prestininzi A. New statistical RI index allow to better track the dynamics of COVID-19 outbreak in Italy. Sci Rep. 2020 Dec 22;10(1):22365. doi: 10.1038/s41598-020-79039-x. PMID: 33353964; PMCID: PMC7755893.

Proietti S, Cucina A, Pensotti A, Fuso A, Marchese C, Nicolini A, Bizzarri M. Tumor reversion and embryo morphogenetic factors. Semin Cancer Biol. 2022 Feb;79:83-90. doi: 10.1016/j.semcancer.2020.09.005. Epub 2020 Sep 10. PMID: 32920125.

Bizzarri M., O. Naimark, J. Nieto-Villar, V. Fedeli and A. Giuliani. Complexity in Biological Organization: Deconstruction (and Subsequent Restating) of Key Concepts. Entropy 2020, 22(8), 885;

Bizzarri M., Giuliani A, Cucina A, Minini M. Redifferentiation therapeutic strategies in cancer. Drug Discov Today. 2020, 25(4):731-738. doi: 10.1016/j.drudis.2020.01.021

Bizzarri M., Giuliani A, Minini M, Monti N, Cucina A. Constraints Shape Cell Function and Morphology by Canalizing the Developmental Path along the Waddington’s Landscape. Bioessays. 2020, 42(4):e1900108. doi: 10.1002/bies.201900108

Bizzarri M., Giuliani A, Monti N, Verna R, Pensotti A, Cucina A. Rediscovery of natural compounds acting via multitarget recognition and noncanonical pharmacodynamical actions. Drug Discov Today. 2020, S1359-6446(20)30080-5. doi: 10.1016/j.drudis.2020.02.010.

Agnese Po, Alessandro Giuliani, Maria Grazia Masiello, Alessandra Cucina, Angela Catizone, Giulia Ricci, Martina Chiacchiarini, Marco Tafani, Elisabetta Ferretti, and Mariano Bizzarri. Phenotypic transitions enacted by microgravity do not alter coherence in gene transcription profile, Nature microgravity, 2019.

Bizzarri M., Giuliani A, Pensotti A, Ratti E, Bertolaso M. Co-emergence and Collapse: The Mesoscopic Approach for Conceptualizing and Investigating the Functional Integration of Organisms. Front Physiol. 2019 Jul 26;10:924. doi: 10.3389/fphys.2019.00924.

128) Proietti S, Cucina A, Pensotti A, Biava PM, Minini M, Monti N, Catizone A, Ricci G, Leonetti E, Harrath AH, Alwasel SH, Bizzarri M. Active Fraction from Embryo Fish Extracts Induces Reversion of the Malignant Invasive Phenotype in Breast Cancer through Down-regulation of TCTP and Modulation of E-cadherin/β-catenin Pathway. Int J Mol Sci. 2019 Apr 30;20(9)

Morabito C, Lanuti P, Caprara GA, Marchisio M, Bizzarri M, Guarnieri S, Mariggiò MA. Physiological Responses of Jurkat Lymphocytes to Simulated Microgravity Conditions. Int J Mol Sci. 2019, 20(8). pii: E1892. doi: 10.3390/ijms20081892

Costantini D, Overi D, Casadei L, Cardinale V, Nevi L, Carpino G, Di Matteo S, Safarikia S, Valerio M, Melandro F, Bizzarri M, Manetti C, Berloco PB, Gaudio E, Alvaro D. Simulated microgravity promotes the formation of tridimensional cultures and stimulates pluripotency and a glycolytic metabolism in human hepatic and biliary tree stem/progenitor cells. Sci Rep. 2019, 9(1):5559. doi: 10.1038/s41598-019-41908-5.

Bizzarri M, Brash DE, Briscoe J, Grieneisen VA, Stern CD, Levin M. A call for a better understanding of causation in cell biology. Nat Rev Mol Cell Biol. 2019. doi: 10.1038/s41580-019-0130-6

Bevilacqua A, Dragotto J, Giuliani A, Bizzarri M. Myo-inositol and D-chiro-inositol (40:1) reverse histological and functional features of polycystic ovary syndrome in a mouse model. J Cell Physiol. 2018 Oct 14. doi: 10.1002/jcp.27623

Proietti S, Catizone A, Masiello MG, Dinicola S, Fabrizi G, Minini M, Ricci G, Verna R, Reiter RJ, Cucina A, Bizzarri M. Increase in motility and invasiveness of MCF7 cancer cells induced by nicotine is abolished by melatonin through inhibition of ERK phosphorylation. J Pineal Res. 2018 Jan 16. doi: 10.1111/jpi.12467

Masiello MG, Verna R, Cucina A, Bizzarri M. Physical constraints in cell fate specification. A case in point: Microgravity and phenotypes differentiation. Prog Biophys Mol Biol. 2018 Jan 4. pii: S0079-6107(17)30313-9. doi: 10.1016/j.pbiomolbio.2018.01.001

Bizzarri M, Masiello MG, Giuliani A, Cucina A. Gravity Constraints Drive Biological Systems Toward Specific Organization Patterns: Commitment of cell specification is constrained by physical cues. Bioessays. 2018 Jan;40(1). doi: 10.1002/bies.201700138. Epub 2017 Nov

Dinicola S, Masiello MG, Proietti S, Coluccia P, Fabrizi G, Catizone A, Ricci G, De Toma G, Bizzarri M, Cucina A. Nicotine increases colon cancer cell migration and invasion through epithelial to mesenchymal transition (EMT): COX-2 involvement. J Cell Physiol. 2017 Dec 7. doi: 10.1002/jcp.26323.

Proietti S, Cucina A, Minini M, Bizzarri M. Melatonin, mitochondria, and the cancer cell. Cell Mol Life Sci. 2017 Nov;74(21):4015-4025

Ranieri D, Proietti S, Dinicola S, Masiello MG, Rosato B, Ricci G, Cucina A, Catizone A, Bizzarri M, Torrisi MR. Simulated microgravity triggers epithelial mesenchymal transition in human keratinocytes. Sci Rep. 2017 Apr 3;7(1):538.

Bizzarri M, Dinicola S, Bevilacqua A, Cucina A. Broad Spectrum Anticancer Activity of Myo-Inositol and Inositol Hexakisphosphate. Int J Endocrinol. 2016.

Bizzarri M., Fuso A, Dinicola S, Cucina A, Bevilacqua A. Pharmacodynamics and pharmacokinetics of inositol(s) in health and disease. Expert Opin Drug Metab Toxicol. 2016 Jul 14:1-16

Bizzarri M, Cucina A. SMT and TOFT: Why and How They are Opposite and Incompatible Paradigms. Acta Biotheor. 2016 , 64(3):221-39

Dinicola S, Fabrizi G, Masiello MG, Proietti S, Palombo A, Minini M, Harrath AH, Alwasel SH, Ricci G, Catizone A, Cucina A, Bizzarri M. Inositol induces mesenchymal-epithelial reversion in breast cancer cells through cytoskeleton rearrangement. Exp Cell Res. 2016 Jul 1;345(1):37-50

Proietti S, Cucina A, Dobrowolny G, D’Anselmi F, Dinicola S, Masiello MG, Pasqualato A, Palombo A, Morini V, Reiter RJ, Bizzarri M. Melatonin down-regulates MDM2 gene expression and enhances p53 acetylation in MCF-7 cells. J Pineal Res. 2014 , 57(1):120-9

Bizzarri M, Cucina A. Tumor and the microenvironment: a chance to reframe the paradigm of carcinogenesis? Biomed Res Int. 2014 :934038

Dinicola S, Chiu TT, Unfer V, Carlomagno G, Bizzarri M. The rationale of the myo-inositol and D-chiro-inositol combined treatment for polycystic ovary syndrome. J Clin Pharmacol. 2014 ;54(10):1079-92

Masiello MG, Cucina A, Proietti S, Palombo A, Coluccia P, D’Anselmi F, Dinicola S, Pasqualato A, Morini V, Bizzarri M. Phenotypic switch induced by simulated microgravity on MDA-MB-231 breast cancer cells. Biomed Res Int. 2014; 2014:652434

Dinicola S, Pasqualato A, Cucina A, Coluccia P, Ferranti F, Canipari R, Catizone A, Proietti S, D’Anselmi F, Ricci G, Palombo A, Bizzarri M. Grape seed extract suppresses MDA-MB231 breast cancer cell migration and invasion. Eur J Nutr. 2014 PMID: 23754570 DOI: 10.1007/s00394-013-0542-6

D’Anselmi F, Masiello MG, Cucina A, Proietti S, Dinicola S, Pasqualato A, Ricci G, Dobrowolny G, Catizone A, Palombo A, Bizzarri M. Microenvironment promotes tumor cell reprogramming in human breast cancer cell lines. PLoS One. 2013; 8(12):e83770

Ferranti F, D’Anselmi F, Caruso M, Lei V, Dinicola S, Pasqualato A, Cucina A, Palombo A, Ricci G, Catizone A, Bizzarri M. TCam-2 seminoma cells exposed to egg-derived microenvironment modify their shape, adhesive pattern and migratory behaviour: a molecular and morphometric analysis. PLoS One. 2013 Oct 1;8(10):e76192

Bizzarri M, Proietti S, Cucina A, Reiter RJ. Molecular mechanisms of the pro-apoptotic actions of melatonin in cancer: a review. Expert Opin Ther Targets. 2013 Dec;17(12):1483-96

Bizzarri M, Palombo A, Cucina A. Theoretical aspects of Systems Biology. Prog Biophys Mol Biol. 2013, 112(1-2):33-43

Dinicola S, Mariggiò MA, Morabito C, Guarnieri S, Cucina A, Pasqualato A, D’Anselmi F, Proietti S, Coluccia P, Bizzarri M. Grape seed extract triggers apoptosis in Caco-2 human colon cancer cells through reactive oxygen species and calcium increase: extracellular signal-regulated kinase involvement. Br J Nutr. 2013, 110(5): 797-809.

Proietti S., Cucina A., Reiter RJ, Bizzarri M., Molecular Mechanisms of Melatonin’s inhibitory actions on Breast Cancers. Cell Mol Life Sci. 2013, 70(12): 2139-2157

Pasqualato A, Palombo A, Cucina A, Mariggiò MA, Galli L, Passaro D, Dinicola S, Proietti S, D’Anselmi F, Coluccia P, Bizzarri M. Quantitative shape analysis of chemoresistant colon cancer cells : correlation between morphotype and phenotype. Exp Cell Res. 2012; 318(7):835-46. PMID: 22342954

Anna Laura Capriotti, Giuseppe Caruso, Chiara Cavaliere, Patrizia Foglia, Mariano Bizzarri, Aldo Laganà. Rapid Resolution Liquid chromatography/High Resolution Tandem Mass Spectrometry to Characterize Metabolic Changes in Subjects Involved in MARS500 Project.
Chromatographia 2011, 73 (suppl. 1): 45-53, DOI: 10.1007/s10337-010-1880-7

Bizzarri M, Giuliani A, Cucina A, D’Anselmi F, Soto AM, Sonnenschein C. Fractal analysis in a systems biology approach to cancer. Semin Cancer Biol. 2011, 21(3):175-82. doi: 10.1016/j.semcancer.2011.04.002. PMID: 21514387

Proietti S, Cucina A, D’Anselmi F, Dinicola S, Pasqualato A, Lisi E, Bizzarri M. Melatonin and vitamin D3 synergistically down-regulate Akt and MDM2 leading to TGFβ-1-dependent growth inhibition of breast cancer cells.
J Pineal Res. 2011, 50(2):150-8. doi: 10.1111/j.1600-079X.2010.00824.x. PMID: 21091766

D’Anselmi F, Valerio M, Cucina A, Galli L, Proietti S, Dinicola S, Pasqualato A, Manetti C, Ricci G, Giuliani A, Bizzarri M. Metabolism and cell shape in cancer: a fractal analysis. Int J Biochem Cell Biol. 2011 , 43(7):1052-8. PMID: 20460170

Dinicola S, Cucina A, Pasqualato A, Proietti S, D’Anselmi F, Pasqua G, Santamaria AR, Coluccia P, Laganà A, Antonacci D, Giuliani A, Bizzarri M. Apoptosis-inducing factor and caspase-dependent apoptotic pathways triggered by different grape seed extracts on human colon cancer cell line Caco-2.
Br J Nutr. 2010, 104(6):824-32. PMID:20540818

Morabito C, Rovetta F, Bizzarri M, Mazzoleni G, Fanò G, Mariggiò MA. Modulation of redox status and calcium handling by extremely low frequency electromagnetic fields in C2C12 muscle cells: A real-time, single-cell approach. Free Radic Biol Med. 2010 , 48(4):579-89. PMID: 20005945

Cucina A, Proietti S, D’Anselmi F, Coluccia P, Dinicola S, Frati L, Bizzarri M. Evidence for a biphasic apoptotic pathway induced by melatonin in MCF-7 breast cancer cells. J Pineal Res. 2009, 46(2):172-80.. PMID: 19175854

Bizzarri M, Cavaliere C, Foglia P, Guarino C, Samperi R, Laganà A. A label-free method based on MALDI-TOF mass spectrometry for the absolute quantitation of troponin T in mouse cardiac tissue. Anal Bioanal Chem. 2008 , 391(5):1969-76. PMID:18421442

Bizzarri M, Cucina A, Conti F, D’Anselmi F. Beyond the oncogene paradigm: understanding complexity in cancerogenesis. Acta Biotheor. 2008 , 56(3):173-96. PMID: 18288572

Cucina A, Biava PM, D’Anselmi F, Coluccia P, Conti F, di Clemente R, Miccheli A, Frati L, Gulino A, Bizzarri M. Zebrafish embryo proteins induce apoptosis in human colon cancer cells (Caco2). Apoptosis. 2006 , 11(9):1617-28. PMID: 16820966

Livraghi, T., Meloni, F., Frosi, A., Lazzaroni, S., Bizzarri M., Frati, L., Biava, P.M. Treatment with stem cell differentiation stage factor of intermediate-advanced hepatocellular carcinoma: an open randomised clinical trial. Oncol. Res. 2005, 15: 399-408. PMID: 16491958

Manetti C, Bianchetti C, Bizzarri M, Casciani L, Castro C, D’Ascenzo G, Delfini M, Di Cocco ME, Laganà A, Miccheli A, Motto M, Conti F. NMR-based metabonomic study of transgenic maize. Phytochemistry. 2004 Dec;65(24):3187-98. PMID: 15561185

Bizzarri M, Cucina A, Valente MG, Tagliaferri F, Borrelli V, Stipa F, Cavallaro A.. Melatonin and vitamin D3 increase TGF-beta1 release and induce growth inhibition in breast cancer cell cultures. J Surg Res. 2003 , 110 (2):332-7. PMID: 12788662

Laganà A, Pardo-Martínez B, Marino A, Fago G, Bizzarri M. Determination of serum total lipid and free N-acetylneuraminic acid in genitourinary malignancies by fluorimetric high performance liquid chromatography. Relevance of free N-acetylneuraminic acid as tumour marker. Clin Chim Acta. 1995, 243 (2):165-79. PMID: 8747492

Lagana A, Martinez BP, Marino A, Fago G, Bizzarri M. Correlation of serum sialic acid fractions as markers for carcinoma of the uterine cervix.
Anticancer Res. 1995, 15(5B):2341-6. PMID: 8572649

A. Lagana, A. Marino, G. Fago, B. Pardo-Martinez, M. Bizzarri. Sensitive assay for melatonin in human serum by liquid chromatography. Anal. Chim. Acta, 1995, 316: 377–385 doi: 10.1016/0003-2670(95)00298-E

Lagana A, Bizzarri M, Marino A, Mancini M. Solid phase extraction and high-performance liquid chromatographic determination of doxophylline in plasma.
Biomed Chromatogr. 1990, 4 (5):205-7. PMID: 2279147

Bizzarri M, Catizone A, Pompei M, Chiappini L, Curini L, Lagana A. Determination of urinary tryptophan and its metabolites along the nicotinic acid pathway by high performance liquid chromatography with ultraviolet detection. Biomed Chromatogr. 1990 , 4 (1):24-7. PMID: 2310838

Bizzarri M, Cucina A, Proietti S., Tumor reversion: mesenchymal-epithelial transition as a critical step in managing the tumor-microenvironment cross talk. Curr Pharm Des. 2017

Martin RR, Montero S., Silva E, Bizzarri M, Cocho G, Mansilla R, Nieto-Villar JM.  Phase transitions in tumor growth: V what can be expected from cancer glycolytic oscillations? Physica A 486 (2017) 762–771

Ranieri D, Proietti S, Dinicola S, Masiello MG, Rosato B, Ricci G, Cucina A, Catizone A, Bizzarri M, Torrisi MR. Simulated microgravity triggers epithelial mesenchymal transition in human keratinocytes. Sci Rep. 2017 Apr 3;7(1):538.

Bizzarri M, Dinicola S, Bevilacqua A, Cucina A. Broad Spectrum Anticancer Activity of Myo-Inositol and Inositol Hexakisphosphate. Int J Endocrinol. 2016.

Bizzarri M., Fuso A, Dinicola S, Cucina A, Bevilacqua A. Pharmacodynamics and pharmacokinetics of inositol(s) in health and disease. Expert Opin Drug Metab Toxicol. 2016 Jul 14:1-16

Bizzarri M, Cucina A. SMT and TOFT: Why and How They are Opposite and Incompatible Paradigms.  Acta Biotheor. 2016 Jun 9

Dinicola S, Fabrizi G, Masiello MG, Proietti S, Palombo A, Minini M, Harrath AH, Alwasel SH, Ricci G, Catizone A, Cucina A, Bizzarri M. Inositol induces mesenchymal-epithelial reversion in breast cancer cells through cytoskeleton rearrangement. Exp Cell Res. 2016 Jul 1;345(1):37-50

Pasta V, Dinicola S, Giuliani A, Harrath AH, Alwasel SH, Tartaglia F, Cucina A, Bizzarri M.  A randomized trial of Boswellia in association with betaine and myo-inositol in the management of breast fibroadenomas. Eur Rev Med Pharmacol Sci. 2016 May;20(9):1860-5

Bevilacqua A, Bizzarri M.   Physiological role and clinical utility of inositols in polycystic ovary syndrome. Best Pract Res Clin Obstet Gynaecol. 2016 Apr

Bizzarri M, Cucina A, Dinicola S, Harrath AH, Alwasel SH, Unfer V, Bevilacqua A.  Does myo-inositol effect on PCOS follicles involve cytoskeleton regulation? Med Hypotheses. 2016 Jun;91:1-5.

Dinicola S, Pasqualato A, Proietti S, Masiello MG, Palombo A, Coluccia P, Canipari R, Catizone A, Ricci G, Harrath AH, Alwasel SH, Cucina A, Bizzarri M. Paradoxical E-cadherin increase in 5FU-resistant colon cancer is unaffected during mesenchymal-epithelial reversion induced by γ-secretase inhibition. Life Sci. 2016 ;145:174-183. doi: 10.1016/j.lfs.2015.12.048

Facchinetti F, Bizzarri M, Benvenga S, D’Anna R, Lanzone A, Soulage C, Di Renzo GC, Hod M, Cavalli P, Chiu TT, Kamenov ZA, Bevilacqua A, Carlomagno G, Gerli S, Oliva MM, Devroey P.   Results from the International Consensus Conference on Myo-inositol and d-chiro-inositol in Obstetrics and Gynecology: the link between metabolic syndrome and PCOS.  Eur J Obstet Gynecol Reprod Biol. 2015 ; 195:72-76. PMID: 26479434.

D Ranieri, A Cucina, M Bizzarri, M Alimandi, MR Torrisi. Microgravity influences circadian clock oscillation in human keratinocytes. FEBS Open Bio, 2015.  doi:10.1016/j.fob.2015.08.012

M Bizzarri, A Cucina, S Proietti  The tumor microenvironment as a target for anticancer treatment Oncobiology and Targets, 2014  1:3-11.

Avitabile D, Ranieri D, Nicolussi A, D’Inzeo S, Capriotti AL, Genovese L, Proietti S, Cucina A, Coppa A, Samperi R, Bizzarri M, Laganà A, Torrisi MR. Peroxiredoxin 2 nuclear levels are regulated by circadian clock synchronization in human keratinocytes.  Int J Biochem Cell Biol. 2014, 53:24-34.

Proietti S, Cucina A, Dobrowolny G, D’Anselmi F, Dinicola S, Masiello MG, Pasqualato A, Palombo A, Morini V, Reiter RJ, Bizzarri M  Melatonin down-regulates MDM2 gene expression and enhances p53 acetylation in MCF-7 cells. J Pineal Res. 2014 , 57(1):120-9

Bizzarri M, Cucina A.  Tumor and the microenvironment: a chance to reframe the paradigm of carcinogenesis?   Biomed Res Int. 2014:934038

Dinicola S, Chiu TT, Unfer V, Carlomagno G, Bizzarri M. The rationale of the myo-inositol and D-chiro-inositol combined treatment for polycystic ovary syndrome.  J Clin Pharmacol. 2014 ;54(10):1079-92

Masiello MG, Cucina A, Proietti S, Palombo A, Coluccia P, D’Anselmi F, Dinicola S, Pasqualato A, Morini V, Bizzarri M.  Phenotypic switch induced by simulated microgravity on MDA-MB-231 breast cancer cells.  Biomed Res Int. 2014;2014:652434

Pisanu ME, Noto A, De Vitis C, Masiello MG, Coluccia P, Proietti S, Giovagnoli MR, Ricci A, Giarnieri E, Cucina A, Ciliberto G, Bizzarri M, Mancini R.  Lung cancer stem cell lose their stemness default state after exposure to microgravity. Biomed Res Int. 2014;2014:470253

Bizzarri M, Monici M, van Loon JJ. How microgravity affects the biology of living systems. Biomed Res Int. ;2015:863075

Bevilacqua A, Carlomagno G, Gerli S, Montanino Oliva M, Devroey P, Lanzone A, Soulange C, Facchinetti F, Carlo Di Renzo G, Bizzarri M, Hod M, Cavalli P, D’Anna R, Benvenga S, Chiu TT, Kamenov ZA. Results from the International Consensus Conference on myo-inositol and D-chiro-inositol in Obstetrics and Gynecology – assisted reproduction technology.  Gynecol Endocrinol. 2015 2:1-6

Bizzarri M., Cucina A., Palombo A., Masiello M.G. Gravity sensing by cells: mechanisms and theoretical grounds. Rend. Fis. Acc. Lincei, 2014, 25: 29-38.

F. Testa, A. Palombo, S. Dinicola, F. D’Anselmi, S. Proietti, A. Pasqualato, M.G. Masiello, P. Coluccia, A. Cucina, M. Bizzarri Fractal analysis of shape changes in murine osteoblasts cultured under simulated microgravity.    Rend. Fis. Acc. Lincei, 2014, 25:39-47

D’Anselmi F, Masiello MG, Cucina A, Proietti S, Dinicola S, Pasqualato A, Ricci G, Dobrowolny G, Catizone A, Palombo A, Bizzarri M.  Microenvironment promotes tumor cell reprogramming in human breast cancer cell lines.  PLoS One. 2013; 8(12):e83770

Pasqualato A, Lei V, Cucina A, Dinicola S, D’Anselmi F, Proietti S, Masiello MG, Palombo A, Bizzarri M. Shape in migration: Quantitative image analysis of migrating chemoresistant HCT-8 colon cancer cells.  Cell Adh Migr. 2013 Sep 1;7(5):450-9

Ferranti F, D’Anselmi F, Caruso M, Lei V, Dinicola S, Pasqualato A, Cucina A, Palombo A, Ricci G, Catizone A, Bizzarri M.  TCam-2 seminoma cells exposed to egg-derived microenvironment modify their shape, adhesive pattern and migratory behaviour: a molecular and morphometric analysis.  PLoS One. 2013 Oct 1;8(10):e76192

Bizzarri M, Proietti S, Cucina A, Reiter RJ.  Molecular mechanisms of the pro-apoptotic actions of melatonin in cancer: a review.  Expert Opin Ther Targets. 2013 Dec;17(12):1483-96

Dinicola S, Pasqualato A, Cucina A, Coluccia P, Ferranti F, Canipari R, Catizone A, Proietti S, D’Anselmi F, Ricci G, Palombo A, Bizzarri M. Grape seed extract suppresses MDA-MB231 breast cancer cell migration and invasion.  Eur J Nutr. 2013 Jun 11.

Bizzarri M, Palombo A, Cucina A.  Theoretical aspects of Systems Biology. Prog Biophys Mol Biol. 2013, 112(1-2):33-43

Dinicola S, Mariggiò MA, Morabito C, Guarnieri S, Cucina A, Pasqualato A, D’Anselmi F, Proietti S, Coluccia P, Bizzarri M. Grape seed extract triggers apoptosis in Caco-2 human colon cancer cells through reactive oxygen species and calcium increase: extracellular signal-regulated kinase involvement. Br J Nutr. 2013, 110(5): 797-809.

Proietti S., Cucina A., Reiter RJ,  Bizzarri M.,  Molecular Mechanisms of Melatonin’s inhibitory actions on Breast Cancers.  Cell Mol Life Sci. 2013, 70(12): 2139-2157

Bizzarri M., Pasqualato A., Cucina A., Pasta V.  Physical forces and non linear dynamics mould fractal cell shape  Histol Histopathol. 2013, 28(2):155-174.

Pasqualato A, Palombo A, Cucina A, Mariggiò MA, Galli L, Passaro D, Dinicola S, Proietti S, D’Anselmi F, Coluccia P, Bizzarri M. Quantitative shape analysis of chemoresistant colon cancer cells : correlation between morphotype and phenotype.  Exp Cell Res. 2012; 318(7):835-46. PMID: 22342954

Dinicola S, Cucina A, Pasqualato A, D’Anselmi F, Proietti S, Lisi E, Pasqua G, Antonacci D, Bizzarri M. Antiproliferative and Apoptotic Effects Triggered by Grape Seed Extract (GSE) versus Epigallocatechin and Procyanidins on Colon Cancer Cell Lines. Int J Mol Sci. 2012;13(1):651-664.  PMID:22312277

Bizzarri M, Giuliani A, Cucina A, D’Anselmi F, Soto AM, Sonnenschein C. Semi Fractal analysis in a systems biology approach to cancer.  Cancer Biol. 2011, 21(3):175-82. doi: 10.1016/j.semcancer.2011.04.002. PMID: 21514387

Dinicola S, D’Anselmi F, Pasqualato A, Proietti S, Lisi E, Cucina A, Bizzarri M. A systems biology approach to cancer: fractals, attractors, and nonlinear dynamics.  OMICS. 2011,  15(3):93-104. PMID: 21319994

Proietti S, Cucina A, D’Anselmi F, Dinicola S, Pasqualato A, Lisi E, Bizzarri M. J Pineal Res. Melatonin and vitamin D3 synergistically down-regulate Akt and MDM2 leading to TGFβ-1-dependent growth inhibition of breast cancer cells.  2011, 50(2):150-8.  doi: 10.1111/j.1600-079X.2010.00824.x. PMID: 21091766

Bizzarri M, Cucina A, Biava PM, Proietti S, D’Anselmi F, Dinicola S, Pasqualato A, Lisi E. Embryonic morphogenetic field induces phenotypic reversion in cancer cells. Review article. Curr Pharm Biotechnol. 2011, 12(2):243-53. PMID: 21044001

D’Anselmi F, Cucina A, Biava PM, Proietti S, Coluccia P, Frati L, Bizzarri M. Zebrafish stem cell differentiation stage factors suppress Bcl-xL release and enhance 5-Fu-mediated apoptosis in colon cancer cells. Curr Pharm Biotechnol. 2011 , 12(2):261-7. PMID: 21043999

D’Anselmi F, Valerio M, Cucina A, Galli L, Proietti S, Dinicola S, Pasqualato A, Manetti C, Ricci G, Giuliani A, Bizzarri M. Metabolism and cell shape in cancer: a fractal analysis. Int J Biochem Cell Biol. 2011 , 43(7):1052-8. PMID: 20460170

Dinicola S, Cucina A, Pasqualato A, Proietti S, D’Anselmi F, Pasqua G, Santamaria AR, Coluccia P, Laganà A, Antonacci D, Giuliani A, Bizzarri M. Apoptosis-inducing factor and caspase-dependent apoptotic pathways triggered by different grape seed extracts on human colon cancer cell line Caco-2. Br J Nutr. 2010,  104(6):824-32.  PMID:20540818

Cucina A, Proietti S, D’Anselmi F, Coluccia P, Dinicola S, Frati L, Bizzarri M. J Pineal Res. Evidence for a biphasic apoptotic pathway induced by melatonin in MCF-7 breast cancer cells. 2009, 46(2):172-80..  PMID: 19175854

Bizzarri M, Cucina A, Conti F, D’Anselmi F. Acta Biotheor. Beyond the oncogene paradigm: understanding complexity in cancerogenesis.  2008 , 56(3):173-96.  PMID:  18288572

Miccheli AT, Miccheli A, Di Clemente R, Valerio M, Coluccia P, Bizzarri M, Conti F. NMR-based metabolic profiling of human hepatoma cells in relation to cell growth by culture media analysis. Biochim Biophys Acta. 2006,  1760 (11):1723-31.   PMID: 17052856

Cucina A, Biava PM, D’Anselmi F, Coluccia P, Conti F, di Clemente R, Miccheli A, Frati L, Gulino A, Bizzarri M. Zebrafish embryo proteins induce apoptosis in human colon cancer cells (Caco2). Apoptosis. 2006 , 11(9):1617-28.   PMID: 16820966

Livraghi, T., Meloni, F., Frosi, A., Lazzaroni, S., Bizzarri M., Frati, L., Biava, P.M. Treatment with stem cell differentiation stage factor of intermediate-advanced hepatocellular carcinoma: an open randomised clinical trial Oncol. Res. 2005, 15: 399-408.  PMID: 16491958

Franchi F, Ielapi T, Bizzarri M, Seminara P. J Embryo extracts opotherapy reduces alpha-fetoprotein levels in hepatocellular carcinoma patients.  Gastroenterol Hepatol. 2005 , 20(9):1467-8.  PMID: 16105144

Bizzarri M, Cucina A, Valente MG, Tagliaferri F, Borrelli V, Stipa F, Cavallaro A.J Melatonin and vitamin D3 increase TGF-beta1 release and induce growth inhibition in breast cancer cell cultures. Surg Res. 2003 , 110 (2):332-7. PMID: 12788662