Selected Publications

Selected Publications

• Bizzarri M, Cucina A, Proietti S., Tumor reversion: mesenchymal-epithelial transition as a critical step in managing the tumor-microenvironment cross talk. Curr Pharm Des. 2017
• Martin RR, Montero S., Silva E, Bizzarri M, Cocho G, Mansilla R, Nieto-Villar JM.  Phase transitions in tumor growth: V what can be expected from cancer glycolytic oscillations? Physica A 486 (2017) 762–771
• Ranieri D, Proietti S, Dinicola S, Masiello MG, Rosato B, Ricci G, Cucina A, Catizone A, Bizzarri M, Torrisi MR. Simulated microgravity triggers epithelial mesenchymal transition in human keratinocytes. Sci Rep. 2017 Apr 3;7(1):538.
• Bizzarri M, Dinicola S, Bevilacqua A, Cucina A. Broad Spectrum Anticancer Activity of Myo-Inositol and Inositol Hexakisphosphate. Int J Endocrinol. 2016.
• Bizzarri M., Fuso A, Dinicola S, Cucina A, Bevilacqua A. Pharmacodynamics and pharmacokinetics of inositol(s) in health and disease. Expert Opin Drug Metab Toxicol. 2016 Jul 14:1-16
• Bizzarri M, Cucina A. SMT and TOFT: Why and How They are Opposite and Incompatible Paradigms.  Acta Biotheor. 2016 Jun 9
• Dinicola S, Fabrizi G, Masiello MG, Proietti S, Palombo A, Minini M, Harrath AH, Alwasel SH, Ricci G, Catizone A, Cucina A, Bizzarri M. Inositol induces mesenchymal-epithelial reversion in breast cancer cells through cytoskeleton rearrangement. Exp Cell Res. 2016 Jul 1;345(1):37-50
• Pasta V, Dinicola S, Giuliani A, Harrath AH, Alwasel SH, Tartaglia F, Cucina A, Bizzarri M.  A randomized trial of Boswellia in association with betaine and myo-inositol in the management of breast fibroadenomas. Eur Rev Med Pharmacol Sci. 2016 May;20(9):1860-5
• Bevilacqua A, Bizzarri M.   Physiological role and clinical utility of inositols in polycystic ovary syndrome. Best Pract Res Clin Obstet Gynaecol. 2016 Apr
• Bizzarri M, Cucina A, Dinicola S, Harrath AH, Alwasel SH, Unfer V, Bevilacqua A.  Does myo-inositol effect on PCOS follicles involve cytoskeleton regulation? Med Hypotheses. 2016 Jun;91:1-5.
• Dinicola S, Pasqualato A, Proietti S, Masiello MG, Palombo A, Coluccia P, Canipari R, Catizone A, Ricci G, Harrath AH, Alwasel SH, Cucina A, Bizzarri M. Paradoxical E-cadherin increase in 5FU-resistant colon cancer is unaffected during mesenchymal-epithelial reversion induced by γ-secretase inhibition. Life Sci. 2016 ;145:174-183. doi: 10.1016/j.lfs.2015.12.048
• Facchinetti F, Bizzarri M, Benvenga S, D’Anna R, Lanzone A, Soulage C, Di Renzo GC, Hod M, Cavalli P, Chiu TT, Kamenov ZA, Bevilacqua A, Carlomagno G, Gerli S, Oliva MM, Devroey P.   Results from the International Consensus Conference on Myo-inositol and d-chiro-inositol in Obstetrics and Gynecology: the link between metabolic syndrome and PCOS.  Eur J Obstet Gynecol Reprod Biol. 2015 ; 195:72-76. PMID: 26479434.
• D Ranieri, A Cucina, M Bizzarri, M Alimandi, MR Torrisi. Microgravity influences circadian clock oscillation in human keratinocytes. FEBS Open Bio, 2015.  doi:10.1016/j.fob.2015.08.012
• M Bizzarri, A Cucina, S Proietti  The tumor microenvironment as a target for anticancer treatment Oncobiology and Targets, 2014  1:3-11.
• Avitabile D, Ranieri D, Nicolussi A, D’Inzeo S, Capriotti AL, Genovese L, Proietti S, Cucina A, Coppa A, Samperi R, Bizzarri M, Laganà A, Torrisi MR. Peroxiredoxin 2 nuclear levels are regulated by circadian clock synchronization in human keratinocytes.  Int J Biochem Cell Biol. 2014, 53:24-34.
• Proietti S, Cucina A, Dobrowolny G, D’Anselmi F, Dinicola S, Masiello MG, Pasqualato A, Palombo A, Morini V, Reiter RJ, Bizzarri M  Melatonin down-regulates MDM2 gene expression and enhances p53 acetylation in MCF-7 cells. J Pineal Res. 2014 , 57(1):120-9
• Bizzarri M, Cucina A.  Tumor and the microenvironment: a chance to reframe the paradigm of carcinogenesis?   Biomed Res Int. 2014:934038
• Dinicola S, Chiu TT, Unfer V, Carlomagno G, Bizzarri M. The rationale of the myo-inositol and D-chiro-inositol combined treatment for polycystic ovary syndrome.  J Clin Pharmacol. 2014 ;54(10):1079-92
• Masiello MG, Cucina A, Proietti S, Palombo A, Coluccia P, D’Anselmi F, Dinicola S, Pasqualato A, Morini V, Bizzarri M.  Phenotypic switch induced by simulated microgravity on MDA-MB-231 breast cancer cells.  Biomed Res Int. 2014;2014:652434
• Pisanu ME, Noto A, De Vitis C, Masiello MG, Coluccia P, Proietti S, Giovagnoli MR, Ricci A, Giarnieri E, Cucina A, Ciliberto G, Bizzarri M, Mancini R.  Lung cancer stem cell lose their stemness default state after exposure to microgravity. Biomed Res Int. 2014;2014:470253
• Bizzarri M, Monici M, van Loon JJ. How microgravity affects the biology of living systems. Biomed Res Int. ;2015:863075
• Bevilacqua A, Carlomagno G, Gerli S, Montanino Oliva M, Devroey P, Lanzone A, Soulange C, Facchinetti F, Carlo Di Renzo G, Bizzarri M, Hod M, Cavalli P, D’Anna R, Benvenga S, Chiu TT, Kamenov ZA. Results from the International Consensus Conference on myo-inositol and D-chiro-inositol in Obstetrics and Gynecology – assisted reproduction technology.  Gynecol Endocrinol. 2015 2:1-6
• Bizzarri M., Cucina A., Palombo A., Masiello M.G. Gravity sensing by cells: mechanisms and theoretical grounds. Rend. Fis. Acc. Lincei, 2014, 25: 29-38.
• F. Testa, A. Palombo, S. Dinicola, F. D’Anselmi, S. Proietti, A. Pasqualato, M.G. Masiello, P. Coluccia, A. Cucina, M. Bizzarri Fractal analysis of shape changes in murine osteoblasts cultured under simulated microgravity.    Rend. Fis. Acc. Lincei, 2014, 25:39-47
• D’Anselmi F, Masiello MG, Cucina A, Proietti S, Dinicola S, Pasqualato A, Ricci G, Dobrowolny G, Catizone A, Palombo A, Bizzarri M.  Microenvironment promotes tumor cell reprogramming in human breast cancer cell lines.  PLoS One. 2013; 8(12):e83770
• Pasqualato A, Lei V, Cucina A, Dinicola S, D’Anselmi F, Proietti S, Masiello MG, Palombo A, Bizzarri M. Shape in migration: Quantitative image analysis of migrating chemoresistant HCT-8 colon cancer cells.  Cell Adh Migr. 2013 Sep 1;7(5):450-9
• Ferranti F, D’Anselmi F, Caruso M, Lei V, Dinicola S, Pasqualato A, Cucina A, Palombo A, Ricci G, Catizone A, Bizzarri M.  TCam-2 seminoma cells exposed to egg-derived microenvironment modify their shape, adhesive pattern and migratory behaviour: a molecular and morphometric analysis.  PLoS One. 2013 Oct 1;8(10):e76192
• Bizzarri M, Proietti S, Cucina A, Reiter RJ.  Molecular mechanisms of the pro-apoptotic actions of melatonin in cancer: a review.  Expert Opin Ther Targets. 2013 Dec;17(12):1483-96
• Dinicola S, Pasqualato A, Cucina A, Coluccia P, Ferranti F, Canipari R, Catizone A, Proietti S, D’Anselmi F, Ricci G, Palombo A, Bizzarri M. Grape seed extract suppresses MDA-MB231 breast cancer cell migration and invasion.  Eur J Nutr. 2013 Jun 11.
• Bizzarri M, Palombo A, Cucina A.  Theoretical aspects of Systems Biology. Prog Biophys Mol Biol. 2013, 112(1-2):33-43
• Dinicola S, Mariggiò MA, Morabito C, Guarnieri S, Cucina A, Pasqualato A, D’Anselmi F, Proietti S, Coluccia P, Bizzarri M. Grape seed extract triggers apoptosis in Caco-2 human colon cancer cells through reactive oxygen species and calcium increase: extracellular signal-regulated kinase involvement. Br J Nutr. 2013, 110(5): 797-809.
• Proietti S., Cucina A., Reiter RJ,  Bizzarri M.,  Molecular Mechanisms of Melatonin’s inhibitory actions on Breast Cancers.  Cell Mol Life Sci. 2013, 70(12): 2139-2157
• Bizzarri M., Pasqualato A., Cucina A., Pasta V.  Physical forces and non linear dynamics mould fractal cell shape  Histol Histopathol. 2013, 28(2):155-174.
• Pasqualato A, Palombo A, Cucina A, Mariggiò MA, Galli L, Passaro D, Dinicola S, Proietti S, D’Anselmi F, Coluccia P, Bizzarri M. Quantitative shape analysis of chemoresistant colon cancer cells : correlation between morphotype and phenotype.  Exp Cell Res. 2012; 318(7):835-46. PMID: 22342954
• Dinicola S, Cucina A, Pasqualato A, D’Anselmi F, Proietti S, Lisi E, Pasqua G, Antonacci D, Bizzarri M. Antiproliferative and Apoptotic Effects Triggered by Grape Seed Extract (GSE) versus Epigallocatechin and Procyanidins on Colon Cancer Cell Lines. Int J Mol Sci. 2012;13(1):651-664.  PMID:22312277
• Bizzarri M, Giuliani A, Cucina A, D’Anselmi F, Soto AM, Sonnenschein C. Semi Fractal analysis in a systems biology approach to cancer.  Cancer Biol. 2011, 21(3):175-82. doi: 10.1016/j.semcancer.2011.04.002. PMID: 21514387
• Dinicola S, D’Anselmi F, Pasqualato A, Proietti S, Lisi E, Cucina A, Bizzarri M. A systems biology approach to cancer: fractals, attractors, and nonlinear dynamics.  OMICS. 2011,  15(3):93-104. PMID: 21319994
• Proietti S, Cucina A, D’Anselmi F, Dinicola S, Pasqualato A, Lisi E, Bizzarri M. J Pineal Res. Melatonin and vitamin D3 synergistically down-regulate Akt and MDM2 leading to TGFβ-1-dependent growth inhibition of breast cancer cells.  2011, 50(2):150-8.  doi: 10.1111/j.1600-079X.2010.00824.x. PMID: 21091766
• Bizzarri M, Cucina A, Biava PM, Proietti S, D’Anselmi F, Dinicola S, Pasqualato A, Lisi E. Embryonic morphogenetic field induces phenotypic reversion in cancer cells. Review article. Curr Pharm Biotechnol. 2011, 12(2):243-53. PMID: 21044001
• D’Anselmi F, Cucina A, Biava PM, Proietti S, Coluccia P, Frati L, Bizzarri M. Zebrafish stem cell differentiation stage factors suppress Bcl-xL release and enhance 5-Fu-mediated apoptosis in colon cancer cells. Curr Pharm Biotechnol. 2011 , 12(2):261-7. PMID: 21043999
• D’Anselmi F, Valerio M, Cucina A, Galli L, Proietti S, Dinicola S, Pasqualato A, Manetti C, Ricci G, Giuliani A, Bizzarri M. Metabolism and cell shape in cancer: a fractal analysis. Int J Biochem Cell Biol. 2011 , 43(7):1052-8. PMID: 20460170
• Dinicola S, Cucina A, Pasqualato A, Proietti S, D’Anselmi F, Pasqua G, Santamaria AR, Coluccia P, Laganà A, Antonacci D, Giuliani A, Bizzarri M. Apoptosis-inducing factor and caspase-dependent apoptotic pathways triggered by different grape seed extracts on human colon cancer cell line Caco-2. Br J Nutr. 2010,  104(6):824-32.  PMID:20540818
• Cucina A, Proietti S, D’Anselmi F, Coluccia P, Dinicola S, Frati L, Bizzarri M. J Pineal Res. Evidence for a biphasic apoptotic pathway induced by melatonin in MCF-7 breast cancer cells. 2009, 46(2):172-80..  PMID: 19175854
• Bizzarri M, Cucina A, Conti F, D’Anselmi F. Acta Biotheor. Beyond the oncogene paradigm: understanding complexity in cancerogenesis.  2008 , 56(3):173-96.  PMID:  18288572
• Miccheli AT, Miccheli A, Di Clemente R, Valerio M, Coluccia P, Bizzarri M, Conti F. NMR-based metabolic profiling of human hepatoma cells in relation to cell growth by culture media analysis. Biochim Biophys Acta. 2006,  1760 (11):1723-31.   PMID: 17052856
• Cucina A, Biava PM, D’Anselmi F, Coluccia P, Conti F, di Clemente R, Miccheli A, Frati L, Gulino A, Bizzarri M. Zebrafish embryo proteins induce apoptosis in human colon cancer cells (Caco2). Apoptosis. 2006 , 11(9):1617-28.   PMID: 16820966
• Livraghi, T., Meloni, F., Frosi, A., Lazzaroni, S., Bizzarri M., Frati, L., Biava, P.M. Treatment with stem cell differentiation stage factor of intermediate-advanced hepatocellular carcinoma: an open randomised clinical trial Oncol. Res. 2005, 15: 399-408.  PMID: 16491958
• Franchi F, Ielapi T, Bizzarri M, Seminara P. J Embryo extracts opotherapy reduces alpha-fetoprotein levels in hepatocellular carcinoma patients.  Gastroenterol Hepatol. 2005 , 20(9):1467-8.  PMID: 16105144
• Bizzarri M, Cucina A, Valente MG, Tagliaferri F, Borrelli V, Stipa F, Cavallaro A.J Melatonin and vitamin D3 increase TGF-beta1 release and induce growth inhibition in breast cancer cell cultures. Surg Res. 2003 , 110 (2):332-7. PMID: 12788662

Article on Books

• Bizzarri M., Cucina A., Palombo A.  The conceptual foundations of Systems Biology: an Introduction. In: Recent Advances in Systems Biology Research. Valente A.X.C.N., Sarkar A.  and Gao Y., Editors. , Nova science pub., New York, 2014.
• Bizzarri M, Dinicola S., Manetti C.  Systems Biology approach to metabolomics in cancer studies.  In:  Systems Biology in Cancer Research and Drug Discovery.  Azmi A. Ed.  , Springer, 2012, ISBN 978-94-007-4818-7.
• Bizzarri M. and Giuliani A. Representing cancer cell trajectories in a phase-space diagram: switching cellular states by biological phase transitions.  In:  Applied Statistics for Network Biology: Methods in Systems Biology. M Dehmer., F. Emmert-Streib, A. Graber, A. Salvador  Eds. Wiley Ed. , 2011.  DOI: 10.1002/9783527638079.ch17
• S. Proietti, A. Cucina,  S. Dinicola, A. Pasqualato, F. D’Anselmi and M. Bizzarri. Molecular and epigenetic effects of Melatonin in Breast Cancer.  In: Melatonin in the Promotion of Health, R.R. Watson Eds., Taylor & Francis, Tucson, 2010 . ISBN  9780849385643 
• M. Bizzarri, F. D’Anselmi, M. Valerio, A. Cucina, S. Proietti, S. Dinicola,A. Pasqualato, C. Manetti, L. Galli, A. Giuliani Metabolomic profile and fractal dimensions in breast cancer cells. In: Metabolomics: Metabolites, Metabolomics and Cancer, ISBN: 978-1-61668-006-0, Editor: Justin S. Knapp and William L. Cabrera, NovaScience, London, 2010 .

Books

• Bizzarri M. (Editor) Conceptual and Methodological challenges in Systems Biology. Springer, lab protocol series Methods in Molecular Biology. 2017
• Bizzarri M.  The New Alchemists: the risk of Genetic Modification  Wit Press (Boston), 2012.  ISBN 978-1-84564-662-2