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System Biology Group

sbglab tumor reversion

About us

The natural world consists of hierarchical levels of complexity that range from subatomic particles and molecules to ecosystems and beyond.

This implies that, in order to explain the features and behavior of a whole system, a theory might be required that would operate at the corresponding hierarchical level, i.e. where self-organization processes take place.


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The Systems Biology Laboratory from the Experimental Medicine Department of La Sapienza (Rome) University is organized into two section:

The Tumor Reversion laboratory,

focusing on those processes that, modulating the cross talk between cancer and their microenvironment can lead to the phenotypic reversion of cancer disease.

The Space Biomedicine Laboratory,

held in association with Thales Alenia Space, dealing with the issue of human life processes in the outer Space.

Summer School

Theories in Biology, Development and Cancer

“…no theory of cancer–or of biology– is acceptable unless it comprehends neoplasia as one of the possible consequences of biological organization

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biological sciences


At the beginning of the 21st century, biology is facing an epistemological crisis which anticipates a paradigm change. Reductionism and the molecular analysis it favors have failed to bring about an understanding of complex phenomena in biology.

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Tumor Reversion

The irreversibility of cancer transformation is a concept taken for granted that proved to be groundless.

Indeed, this belief can hardly accommodate with results provided by early studies in which cancer cells were co-cultured within morphogenetic fields, showing that the tumor may successfully ‘revert’ into a normal phenotype.

Indeed, it is now widely accepted that essentially all cell types can be reprogrammed, at least in vitro.

Research Projects

Environment-organism interaction: the epigenetic point of view.

What molecular mechanisms regulate cell senescence and organism aging? Why aging processes show different onset, duration and intensity in different subjects?

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sbglab research molecules

Molecules of pharmacological interest

Medical control of cancer may greatly benefit from the pharmaceutical potential of natural-derived compounds.

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Life in space: an unexpected thoughtful model

Gravity has constantly influenced both physical and biological phenomena throughout Earth’s history.

The gravitational field has played a major role in shaping evolution when life moved from water to land.

However, gravity may influence in a more deep and subtle fashion the way the cells behave and build themselves.

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“He who loves practice without theory is like the sailor who boards ship without a rudder and compass and never knows where he is going”.


Where are Biological Sciences Going?

The natural world consists of hierarchical levels of complexity that range from subatomic particles and molecules to ecosystems and beyond.

Cooperations & Partners